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Hip1 huntingtin interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 215114, updated on 23-Jun-2021

Summary

Official Symbol
Hip1provided by MGI
Official Full Name
huntingtin interacting protein 1provided by MGI
Primary source
MGI:MGI:1099804
See related
Ensembl:ENSMUSG00000039959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIP; mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
Expression
Ubiquitous expression in lung adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 12.6) and 27 other tissues See more
Orthologs
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Genomic context

See Hip1 in Genome Data Viewer
Location:
5 G2; 5 75.18 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135435350..135574167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135406496..135545323, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135882388..136020992, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene nuclear pore membrane protein 121 Neighboring gene microRNA 7033 Neighboring gene predicted gene, 52790 Neighboring gene chemokine (C-C motif) ligand 26 Neighboring gene chemokine (C-C motif) ligand 24

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4113, MGC27616

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
huntingtin-interacting protein 1
Names
HIP-I
huntingtin-interacting protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382848.1NP_001369777.1  huntingtin-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024608
    Conserved Domains (4) summary
    smart00307
    Location:772970
    ILWEQ; I/LWEQ domain
    COG1196
    Location:363602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:7272
    ANTH; ANTH domain
    pfam16515
    Location:454538
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  2. NM_146001.2NP_666113.2  huntingtin-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_666113.2

    Status: VALIDATED

    Source sequence(s)
    AK147246, BC017516, BY309818, CF746398
    Consensus CDS
    CCDS51663.1
    UniProtKB/Swiss-Prot
    Q8VD75
    Related
    ENSMUSP00000059033.9, ENSMUST00000060311.12
    Conserved Domains (5) summary
    smart00307
    Location:8061004
    ILWEQ; I/LWEQ domain
    COG1196
    Location:397636
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:42307
    ANTH; ANTH domain
    pfam16515
    Location:482572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)

RNA

  1. NR_168637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024608

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135435350..135574167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240878.4XP_011239180.1  huntingtin-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011239180.1

    UniProtKB/Swiss-Prot
    Q8VD75
    Conserved Domains (5) summary
    smart00307
    Location:8061004
    ILWEQ; I/LWEQ domain
    COG1196
    Location:397636
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:42307
    ANTH; ANTH domain
    pfam16515
    Location:482572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)
  2. XM_036164986.1XP_036020879.1  huntingtin-interacting protein 1 isoform X1

    Conserved Domains (4) summary
    smart00307
    Location:8141012
    ILWEQ; I/LWEQ domain
    COG1196
    Location:389644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:39306
    ANTH; ANTH domain
    pfam16515
    Location:488580
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  3. XM_036164985.1XP_036020878.1  huntingtin-interacting protein 1 isoform X1

    Conserved Domains (4) summary
    smart00307
    Location:8141012
    ILWEQ; I/LWEQ domain
    COG1196
    Location:389644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:39306
    ANTH; ANTH domain
    pfam16515
    Location:488580
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  4. XM_036164989.1XP_036020882.1  huntingtin-interacting protein 1 isoform X4

    Conserved Domains (4) summary
    smart00307
    Location:780978
    ILWEQ; I/LWEQ domain
    COG1196
    Location:355610
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:7272
    ANTH; ANTH domain
    pfam16515
    Location:454546
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  5. XM_036164990.1XP_036020883.1  huntingtin-interacting protein 1 isoform X5

    Conserved Domains (4) summary
    smart00307
    Location:772970
    ILWEQ; I/LWEQ domain
    COG1196
    Location:363602
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:7272
    ANTH; ANTH domain
    pfam16515
    Location:454538
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  6. XM_036164987.1XP_036020880.1  huntingtin-interacting protein 1 isoform X3

    Conserved Domains (4) summary
    smart00307
    Location:789987
    ILWEQ; I/LWEQ domain
    COG1196
    Location:364619
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:15281
    ANTH; ANTH domain
    pfam16515
    Location:463555
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  7. XM_036164988.1XP_036020881.1  huntingtin-interacting protein 1 isoform X3

    Conserved Domains (4) summary
    smart00307
    Location:789987
    ILWEQ; I/LWEQ domain
    COG1196
    Location:364619
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:15281
    ANTH; ANTH domain
    pfam16515
    Location:463555
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RNA

  1. XR_004942493.1 RNA Sequence

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