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Camk1g calcium/calmodulin-dependent protein kinase I gamma [ Mus musculus (house mouse) ]

Gene ID: 215303, updated on 11-Apr-2024

Summary

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Official Symbol
Camk1gprovided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase I gammaprovided by MGI
Primary source
MGI:MGI:2388073
See related
Ensembl:ENSMUSG00000016179 AllianceGenome:MGI:2388073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLICK III; CLICK-III; CaMKIgamma
Summary
Enables calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Located in endomembrane system and plasma membrane. Part of calcium- and calmodulin-dependent protein kinase complex. Is expressed in several structures, including genitourinary system; heart; nervous system; and retina. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 15.3), whole brain E14.5 (RPKM 12.6) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Camk1g in Genome Data Viewer
Location:
1 H6; 1 97.74 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (193028654..193052636, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193346346..193370355, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene G0/G1 switch gene 2 Neighboring gene laminin, beta 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195164577-195164848 Neighboring gene predicted gene, 51741 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195273620-195273803 Neighboring gene VISTA enhancer mm935 Neighboring gene STARR-seq mESC enhancer starr_03474 Neighboring gene predicted gene, 38022 Neighboring gene predicted gene, 31753

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Takemoto-Kimura S, et al. Neuron, 2007 Jun 7. PMID 17553424
  2. Role of SODD in regulation of tumor necrosis factor responses. Takada H, et al. Mol Cell Biol, 2003 Jun. PMID 12748303, Free PMC Article
  3. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. Ageta-Ishihara N, et al. J Neurosci, 2009 Oct 28. PMID 19864584, Free PMC Article
  4. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Pang ZP, et al. J Biol Chem, 2010 Oct 29. PMID 20729199, Free PMC Article
  5. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Takemoto-Kimura S, et al. J Biol Chem, 2003 May 16. PMID 12637513

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
    Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
  2. CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
    Title: Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
  3. CL3 may represent a key element in the Ca(2+)-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons.
    Title: Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC30513

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1G
Names
caM kinase I gamma
caM kinase IG
caM-KI gamma
caMK-like CREB kinase III
caMKI gamma
caMKIG
NP_001408321.1
NP_001408322.1
NP_659066.1
XP_030108815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421392.1 → NP_001408321.1  calcium/calmodulin-dependent protein kinase type 1G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022675

  2. NM_001421393.1 → NP_001408322.1  calcium/calmodulin-dependent protein kinase type 1G isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022675

  3. NM_144817.3 → NP_659066.1  calcium/calmodulin-dependent protein kinase type 1G isoform 2

    See identical proteins and their annotated locations for NP_659066.1

    Status: VALIDATED

    Source sequence(s)
    AC022675
    Consensus CDS
    CCDS15638.1
    UniProtKB/Swiss-Prot
    Q91VB2
    Related
    ENSMUSP00000016323.5, ENSMUST00000016323.11
    Conserved Domains (2) summary
    smart00220
    Location:23 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14166
    Location:19 → 303
    STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    193028654..193052636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252955.2 → XP_030108815.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 207
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VB2.1 GenPept UniProtKB/Swiss-Prot:Q91VB2

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