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Csrnp1 cysteine-serine-rich nuclear protein 1 [ Mus musculus (house mouse) ]

Gene ID: 215418, updated on 5-Mar-2024

Summary

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Official Symbol
Csrnp1provided by MGI
Official Full Name
cysteine-serine-rich nuclear protein 1provided by MGI
Primary source
MGI:MGI:2387989
See related
Ensembl:ENSMUSG00000032515 AllianceGenome:MGI:2387989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Axud1; URAX1; taip-3; CSRNP-1; 4931429D10Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including face morphogenesis; platelet-derived growth factor receptor signaling pathway; and roof of mouth development. Located in nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 18.0), testis adult (RPKM 16.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Csrnp1 in Genome Data Viewer
Location:
9 F4; 9 71.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119800229..119813808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119971163..119984742, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119887435-119887544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119888013-119888122 Neighboring gene STARR-positive B cell enhancer ABC_E6811 Neighboring gene STARR-positive B cell enhancer ABC_E2922 Neighboring gene STARR-positive B cell enhancer ABC_E3866 Neighboring gene predicted gene, 33800 Neighboring gene STARR-seq mESC enhancer starr_25485 Neighboring gene STARR-seq mESC enhancer starr_25486 Neighboring gene STARR-positive B cell enhancer ABC_E9780 Neighboring gene xin actin-binding repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling. Ye X, et al. Exp Cell Res, 2017 Oct 15. PMID 28830684
  2. Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis. Chen WV, et al. Nat Genet, 2004 Mar. PMID 14981515
  3. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. Ze Y, et al. J Biomed Mater Res A, 2014 Feb. PMID 23533084
  4. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
  5. PDGF signaling specificity is mediated through multiple immediate early genes. Schmahl J, et al. Nat Genet, 2007 Jan. PMID 17143286

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway.
    Title: Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
  2. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs
    Title: Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine/serine-rich nuclear protein 1
Names
AXIN1 up-regulated 1
TGF-beta induced apoptosis protein 3
axin-1 up-regulated gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357560.1 → NP_001344489.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC124662, AK029893
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Related
    ENSMUSP00000150628.2, ENSMUST00000214058.2
    Conserved Domains (1) summary
    pfam16019
    Location:80 → 303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  2. NM_001357561.1 → NP_001344490.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC124662, AK140213
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Related
    ENSMUSP00000035101.8, ENSMUST00000035101.9
    Conserved Domains (1) summary
    pfam16019
    Location:80 → 303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  3. NM_001357562.1 → NP_001344491.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC117245, AC124662
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80 → 303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  4. NM_153287.4 → NP_695019.1  cysteine/serine-rich nuclear protein 1

    See identical proteins and their annotated locations for NP_695019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC117245, AC124662
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80 → 303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119800229..119813808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512040.4 → XP_006512103.1  cysteine/serine-rich nuclear protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006512103.1

    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80 → 303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59054.1 GenPept UniProtKB/Swiss-Prot:P59054

Gene LinkOut

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