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Ctnna3 catenin (cadherin associated protein), alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 216033, updated on 25-Jan-2022

Summary

Official Symbol
Ctnna3provided by MGI
Official Full Name
catenin (cadherin associated protein), alpha 3provided by MGI
Primary source
MGI:MGI:2661445
See related
Ensembl:ENSMUSG00000060843 AllianceGenome:MGI:2661445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vr22; Catna3; 4933408A16; 4930429L08Rik
Summary
Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cell-cell adhesion. Located in adherens junction; fascia adherens; and lamellipodium. Is expressed in cardiac muscle tissue and skin of male preputial swelling. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis adult (RPKM 9.1), heart adult (RPKM 3.0) and 1 other tissue See more
Orthologs
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Genomic context

See Ctnna3 in Genome Data Viewer
Location:
10; 10 B4- B5.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63265877..64841174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63430098..65003667)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62892846..64466415)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene ring finger protein 7 like Neighboring gene predicted gene, 30644 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in fascia adherens IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fascia adherens IDA
Inferred from Direct Assay
more info
PubMed 
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
catenin alpha-3
Names
alpha T-catenin
alpha-catenin-like protein
alphaT-catenin
cadherin-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164376.1NP_001157848.1  catenin alpha-3 isoform 1

    See identical proteins and their annotated locations for NP_001157848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK142745
    Consensus CDS
    CCDS23901.1
    UniProtKB/Swiss-Prot
    Q65CL1
    Related
    ENSMUSP00000101080.2, ENSMUST00000105440.8
    Conserved Domains (1) summary
    pfam01044
    Location:18856
    Vinculin; Vinculin family
  2. NM_001164519.1NP_001157991.1  catenin alpha-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC113544, AC153511, AC153513, AC153514, AC153926, AC158604, AC158638, AC158806
    Conserved Domains (1) summary
    pfam01044
    Location:15589
    Vinculin; Vinculin family
  3. NM_177612.3NP_808280.2  catenin alpha-3 isoform 1

    See identical proteins and their annotated locations for NP_808280.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC153513, AK030166, AK142745
    Consensus CDS
    CCDS23901.1
    UniProtKB/Swiss-Prot
    Q65CL1
    Related
    ENSMUSP00000101081.2, ENSMUST00000105441.8
    Conserved Domains (1) summary
    pfam01044
    Location:18856
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63265877..64841174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513475.4XP_006513538.1  catenin alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_006513538.1

    UniProtKB/Swiss-Prot
    Q65CL1
    Conserved Domains (1) summary
    pfam01044
    Location:18856
    Vinculin; Vinculin family
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