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Trappc10 trafficking protein particle complex 10 [ Mus musculus (house mouse) ]

Gene ID: 216131, updated on 5-Mar-2024

Summary

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Official Symbol
Trappc10provided by MGI
Official Full Name
trafficking protein particle complex 10provided by MGI
Primary source
MGI:MGI:1336209
See related
Ensembl:ENSMUSG00000000374 AllianceGenome:MGI:1336209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm870; Tmem1; b2b2416Clo; b2b2613Clo; B230307C21Rik
Summary
Predicted to be involved in early endosome to Golgi transport and intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be part of TRAPPII protein complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study agnathia-otocephaly complex and velocardiofacial syndrome. Orthologous to human TRAPPC10 (trafficking protein particle complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 30.2), large intestine adult (RPKM 27.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78021256..78080479, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78185422..78244645, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6877 Neighboring gene glutamine amidotransferase like class 1 domain containing 3A Neighboring gene STARR-seq mESC enhancer starr_27217 Neighboring gene PWP2 periodic tryptophan protein homolog (yeast) Neighboring gene STARR-seq mESC enhancer starr_27219 Neighboring gene predicted gene, 30122 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3894 Neighboring gene STARR-seq mESC enhancer starr_27222 Neighboring gene microRNA 7659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice. Rawlins LE, et al. PLoS Genet, 2022 Mar. PMID 35298461, Free PMC Article
  2. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Wang J, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716696, Free PMC Article
  3. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
  4. High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21. Cole SE, et al. Mamm Genome, 1999 Mar. PMID 10051316
  5. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Wiltshire T, et al. Genome Res, 1999 Dec. PMID 10613844, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPPII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
trafficking protein particle complex subunit 10
Names
TRAPP subunit TMEM1
trafficking protein particle complex subunit TMEM1
transmembrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081055.2 → NP_001074524.1  trafficking protein particle complex subunit 10

    See identical proteins and their annotated locations for NP_001074524.1

    Status: VALIDATED

    Source sequence(s)
    AC164573
    Consensus CDS
    CCDS35959.1
    UniProtKB/Swiss-Prot
    F8VQF9, Q3TLI0, Q811H4
    Related
    ENSMUSP00000000384.7, ENSMUST00000000384.8
    Conserved Domains (1) summary
    pfam12584
    Location:1067 → 1245
    TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78021256..78080479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245014.2 → XP_030100874.1  trafficking protein particle complex subunit 10 isoform X1

    Conserved Domains (1) summary
    pfam12584
    Location:828 → 1054
    TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TLI0.3 GenPept UniProtKB/Swiss-Prot:Q3TLI0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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