U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plppr3 phospholipid phosphatase related 3 [ Mus musculus (house mouse) ]

Gene ID: 216152, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Plppr3provided by MGI
Official Full Name
phospholipid phosphatase related 3provided by MGI
Primary source
MGI:MGI:2388640
See related
Ensembl:ENSMUSG00000035835 AllianceGenome:MGI:2388640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prg2; Lppr3
Summary
Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in nervous system and sensory organ. Orthologous to human PLPPR3 (phospholipid phosphatase related 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 149.6), CNS E14 (RPKM 137.8) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Plppr3 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79696309..79710948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79860475..79874958, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79314980-79315089 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 6910 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Broggini T, et al. Aging (Albany NY), 2016 Oct 15. PMID 27744421, Free PMC Article
  2. Systematic expression analysis of plasticity-related genes in mouse brain development brings PRG4 into play. Gross I, et al. Dev Dyn, 2022 Apr. PMID 34622503
  3. TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. Yaguchi H, et al. J Biol Chem, 2012 Apr 6. PMID 22337885, Free PMC Article
  4. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
  5. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Cheng J, et al. Neuron, 2016 Oct 5. PMID 27641493, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA4076

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phospholipid phosphatase-related protein type 3
Names
PRG-2
inactive phospholipid phosphatase PLPPR3
lipid phosphate phosphatase-related protein type 3
plasticity related gene 2
plasticity-related gene 2 protein
NP_001164406.1
NP_001408352.1
NP_001408353.1
NP_001408354.1
NP_001408355.1
NP_001408358.1
NP_001408359.1
NP_001408360.1
NP_859009.2
XP_030100879.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170935.1 → NP_001164406.1  phospholipid phosphatase-related protein type 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF541278, BC098099
    Consensus CDS
    CCDS48622.1
    UniProtKB/TrEMBL
    E9QAX3
    Related
    ENSMUSP00000130695.2, ENSMUST00000167250.8
    Conserved Domains (1) summary
    cd03384
    Location:127 → 276
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_001421423.1 → NP_001408352.1  phospholipid phosphatase-related protein type 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC151846
    UniProtKB/TrEMBL
    A0A0R3P9D0

  3. NM_001421424.1 → NP_001408353.1  phospholipid phosphatase-related protein type 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC151846
    UniProtKB/TrEMBL
    A0A0R3P9D0

  4. NM_001421425.1 → NP_001408354.1  phospholipid phosphatase-related protein type 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC151846
    UniProtKB/TrEMBL
    A0A0R3P9D0

  5. NM_001421426.1 → NP_001408355.1  phospholipid phosphatase-related protein type 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151846

  6. NM_001421429.1 → NP_001408358.1  phospholipid phosphatase-related protein type 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151846

  7. NM_001421430.1 → NP_001408359.1  phospholipid phosphatase-related protein type 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC151846

  8. NM_001421431.1 → NP_001408360.1  phospholipid phosphatase-related protein type 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151846

  9. NM_181681.3 → NP_859009.2  phospholipid phosphatase-related protein type 3 isoform 1

    See identical proteins and their annotated locations for NP_859009.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC151846
    Consensus CDS
    CCDS35971.1
    UniProtKB/Swiss-Prot
    Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
    UniProtKB/TrEMBL
    A0A0R3P9D0
    Related
    ENSMUSP00000089979.5, ENSMUST00000092325.11
    Conserved Domains (1) summary
    cd03384
    Location:127 → 276
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RNA

  1. NR_033210.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF541278, AK220474, BC079534
    Related
    ENSMUST00000166057.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79696309..79710948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245019.2 → XP_030100879.1  phospholipid phosphatase-related protein type 3 isoform X1

    UniProtKB/Swiss-Prot
    Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
    UniProtKB/TrEMBL
    A0A0R3P9D0
    Conserved Domains (1) summary
    cd03384
    Location:127 → 276
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPB0.1 GenPept UniProtKB/Swiss-Prot:Q7TPB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous