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Gls2 glutaminase 2 (liver, mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 216456, updated on 18-May-2021

Summary

Official Symbol
Gls2provided by MGI
Official Full Name
glutaminase 2 (liver, mitochondrial)provided by MGI
Primary source
MGI:MGI:2143539
See related
Ensembl:ENSMUSG00000044005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L; GA; GLS; Lga; AI195532; A330074B06Rik
Expression
Biased expression in liver adult (RPKM 304.4) and liver E18 (RPKM 21.8) See more
Orthologs
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Genomic context

See Gls2 in Genome Data Viewer
Location:
10; 10 D3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128030504..128045873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128194635..128210004)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127631691..127647060)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene predicted gene 4556 Neighboring gene SPRY domain containing 4 Neighboring gene timeless circadian clock 1 Neighboring gene predicted gene, 26847 Neighboring gene major intrinsic protein of lens fiber

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4146

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutamate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutaminase liver isoform, mitochondrial
Names
L-glutaminase
L-glutamine amidohydrolase
liver mitochondrial glutaminase
NP_001028436.2
NP_001272706.1
NP_001272708.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033264.3NP_001028436.2  glutaminase liver isoform, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001028436.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC135859, AK220231
    Consensus CDS
    CCDS24263.1
    UniProtKB/Swiss-Prot
    Q571F8
    Related
    ENSMUSP00000047376.7, ENSMUST00000044776.13
    Conserved Domains (4) summary
    sd00045
    Location:490516
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:490572
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:72155
    EF-hand_14; EF-hand domain
    pfam04960
    Location:177463
    Glutaminase
  2. NM_001285777.1NP_001272706.1  glutaminase liver isoform, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC135859
    Conserved Domains (4) summary
    cd00204
    Location:301389
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:17274
    Glutaminase; Glutaminase
    pfam13637
    Location:331383
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:301327
    ANK; ANK repeat [structural motif]
  3. NM_001285779.1NP_001272708.1  glutaminase liver isoform, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001272708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC135859
    Conserved Domains (4) summary
    cd00204
    Location:225313
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04960
    Location:1198
    Glutaminase; Glutaminase
    pfam13637
    Location:255307
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:225251
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128030504..128045873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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