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Dynlt2a1 dynein light chain Tctex-type 2A1 [ Mus musculus (house mouse) ]

Gene ID: 21647, updated on 8-Feb-2024

Summary

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Official Symbol
Dynlt2a1provided by MGI
Official Full Name
dynein light chain Tctex-type 2A1provided by MGI
Primary source
MGI:MGI:98642
See related
Ensembl:ENSMUSG00000079707 AllianceGenome:MGI:98642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LC2; Tcte3; Dynlt2; Tcte-3; Tctex2; Tctex4; Tctex-2; Tctex-4; D17Leh117c
Summary
This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene is the most distal copy of the three genes. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis adult (RPKM 436.0) See more
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Genomic context

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Location:
17 A2; 17 8.95 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15233025..15261821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15027154..15041559, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ER membrane associated RNA degradation like 2 Neighboring gene STARR-seq mESC enhancer starr_41898 Neighboring gene predicted gene 3255 Neighboring gene dynein light chain Tctex-type 2A2 Neighboring gene ER membrane associated RNA degradation like 1 Neighboring gene predicted gene, 52298 Neighboring gene STARR-seq mESC enhancer starr_41899 Neighboring gene ER membrane associated RNA degradation Neighboring gene predicted gene, 53990 Neighboring gene STARR-seq mESC enhancer starr_41900 Neighboring gene predicted gene, 35343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia. Rashid S, et al. Reproduction, 2010 Jan. PMID 19778998
  2. The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis. Bai X, et al. Biochem Biophys Res Commun, 2003 Jul 18. PMID 12849985
  3. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. Neesen J, et al. Cytogenet Genome Res, 2002. PMID 12584439
  4. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Rappold GA, et al. Genomics, 1992 Aug. PMID 1505969
  5. Tctex2: a sperm tail surface protein mapping to the t-complex. Huw LY, et al. Dev Biol, 1995 Jul. PMID 7601308

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results support a role of Tcte3-3 in generation of sperm motility as well as in male germ cell differentiation
    Title: Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.
  2. Data show that casein kinase 2beta interacts specifically with Tctex4 both in a yeast two-hybrid system and in an in vitro interaction assay.
    Title: The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein light chain Tctex-type protein 2
Names
T-complex testis-specific protein 2
T-complex testis-specific protein 3
T-complex-associated testis-expressed protein 3
T-complex-associated testis-expressed protein 4
t-complex testis-expressed 4
t-complex-associated testis expressed 3
tctex1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011560.3 → NP_035690.2  dynein light chain Tctex-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035690.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK006370, BU919334, CN835332, CN842925
    Consensus CDS
    CCDS28408.1
    UniProtKB/TrEMBL
    A0A0R4J284
    Related
    ENSMUSP00000036704.7, ENSMUST00000040746.8
    Conserved Domains (1) summary
    pfam03645
    Location:94 → 189
    Tctex-1; Tctex-1 family

  2. NM_198104.2 → NP_932772.1  dynein light chain Tctex-type protein 2 isoform 2

    See identical proteins and their annotated locations for NP_932772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AY172988, BU919334, CN835332, CN842925
    Consensus CDS
    CCDS28409.1
    UniProtKB/Swiss-Prot
    P11985
    Related
    ENSMUSP00000095010.5, ENSMUST00000097398.12
    Conserved Domains (1) summary
    pfam03645
    Location:37 → 137
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15233025..15261821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160473.1 → XP_036016366.1  dynein light chain Tctex-type protein 2 isoform X4

  2. XM_036160470.1 → XP_036016363.1  dynein light chain Tctex-type protein 2 isoform X1

  3. XM_036160471.1 → XP_036016364.1  dynein light chain Tctex-type protein 2 isoform X2

  4. XM_036160472.1 → XP_036016365.1  dynein light chain Tctex-type protein 2 isoform X3

RNA

  1. XR_004939506.1 RNA Sequence

  2. XR_004939508.1 RNA Sequence

  3. XR_004939507.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11985.2 GenPept UniProtKB/Swiss-Prot:P11985

Gene LinkOut

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