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Tead1 TEA domain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 21676, updated on 26-Jul-2021

Summary

Official Symbol
Tead1provided by MGI
Official Full Name
TEA domain family member 1provided by MGI
Primary source
MGI:MGI:101876
See related
Ensembl:ENSMUSG00000055320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtrge; TEAD-; TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik
Expression
Broad expression in bladder adult (RPKM 16.6), heart adult (RPKM 14.4) and 24 other tissues See more
Orthologs
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Genomic context

See Tead1 in Genome Data Viewer
Location:
7; 7 F1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (112278563..112505991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112679356..112906784)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (119822834..120050319)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene parvin, alpha Neighboring gene parvin, alpha, opposite strand Neighboring gene predicted gene, 24154 Neighboring gene predicted gene, 40451 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lateral mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of TEAD-YAP complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IC
Inferred by Curator
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-1
Names
NTEF-1
TCF-13
transcription factor 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166584.2NP_001160056.2  transcriptional enhancer factor TEF-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), which results from the use of a non-AUG (AUU) translation initiation codon.
    Source sequence(s)
    AC104930, AK140307
    Consensus CDS
    CCDS52365.1
    Related
    ENSMUSP00000060671.11, ENSMUST00000059768.18
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain
  2. NM_001166585.2NP_001160057.2  transcriptional enhancer factor TEF-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (3) lacks two internal protein segments compared to variant 1.
    Source sequence(s)
    AC104930, AK140307, BC060138
    Consensus CDS
    CCDS52367.1
    Related
    ENSMUSP00000081755.7, ENSMUST00000084705.13
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain
  3. NM_009346.4NP_033372.2  transcriptional enhancer factor TEF-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC104930, AK140307, AK148375
    Consensus CDS
    CCDS52366.1
    Related
    ENSMUSP00000159345.2, ENSMUST00000239404.2
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    112278563..112505991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175559.2: Suppressed sequence

    Description
    NM_175559.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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