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Nags N-acetylglutamate synthase [ Mus musculus (house mouse) ]

Gene ID: 217214, updated on 5-Jan-2022

Summary

Official Symbol
Nagsprovided by MGI
Official Full Name
N-acetylglutamate synthaseprovided by MGI
Primary source
MGI:MGI:2387600
See related
Ensembl:ENSMUSG00000048217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
argA; 1700120E20Rik
Summary
Enables acetyl-CoA:L-glutamate N-acetyltransferase activity. Acts upstream of or within glutamate metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver adult (RPKM 57.5), duodenum adult (RPKM 38.0) and 7 other tissues See more
Orthologs
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Genomic context

See Nags in Genome Data Viewer
Location:
11; 11 D
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102036339..102040354)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102145513..102149528)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (102006901..102010790)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 39394 Neighboring gene Ppih pseudogene Neighboring gene predicted gene 11586 Neighboring gene transmembrane protein 101 Neighboring gene LSM12 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA:L-glutamate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyl-CoA:L-glutamate N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyl-CoA:L-glutamate N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables acetylglutamate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables arginine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methione N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glutamate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within urea cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
N-acetylglutamate synthase, mitochondrial
Names
amino-acid N-acetyltransferase
amino-acid acetyltransferase
NP_665828.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145829.2NP_665828.1  N-acetylglutamate synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_665828.1

    Status: VALIDATED

    Source sequence(s)
    AI415708, AK075765, AL591145
    Consensus CDS
    CCDS25488.1
    UniProtKB/Swiss-Prot
    Q8R4H7
    Related
    ENSMUSP00000050258.6, ENSMUST00000055409.6
    Conserved Domains (3) summary
    PRK04531
    Location:108518
    PRK04531; acetylglutamate kinase; Provisional
    pfam04768
    Location:350513
    NAT; NAT, N-acetyltransferase, of N-acetylglutamate synthase
    cl00452
    Location:95364
    AAK; Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102036339..102040354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178053.4: Suppressed sequence

    Description
    NM_178053.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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