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Adad1 adenosine deaminase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 21744, updated on 21-Apr-2024

Summary

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Official Symbol
Adad1provided by MGI
Official Full Name
adenosine deaminase domain containing 1provided by MGI
Primary source
MGI:MGI:103258
See related
Ensembl:ENSMUSG00000027719 AllianceGenome:MGI:103258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tenr
Summary
Enables RNA binding activity. Acts upstream of or within spermatid development. Located in nucleus. Is expressed in brain; genitourinary system; and inner ear. Orthologous to human ADAD1 (adenosine deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 32.6) See more
Orthologs
human all
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Genomic context

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Location:
3 B; 3 18.3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (37117805..37165661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (37063656..37111512)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, mitochondrial 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07428 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene STARR-seq mESC enhancer starr_07429 Neighboring gene STARR-seq mESC enhancer starr_07431 Neighboring gene STARR-seq mESC enhancer starr_07432 Neighboring gene zinc finger, CCHC domain containing 17 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene 12584 Neighboring gene interleukin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Lu Y, et al. Andrology, 2023 May. PMID 36698249,
  2. Disruption of murine Tenr results in teratospermia and male infertility. Connolly CM, et al. Dev Biol, 2005 Feb 1. PMID 15649457
  3. Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. Pascal JM, et al. J Mol Biol, 2002 Jun 21. PMID 12079346
  4. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Lyons PA, et al. Genome Res, 2000 Apr. PMID 10779485, Free PMC Article
  5. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Schumacher JM, et al. Biol Reprod, 1995 Jun. PMID 7543294

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculusdagger.
    Title: ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculus†.
  2. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
    Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
  3. Targeted mutation of the Tenr gene causes male sterility. Tenr mutant males have a reduced sperm count, and Tenr-/- sperm show a decrease in motility and an increase in malformed heads.
    Title: Disruption of murine Tenr results in teratospermia and male infertility.
  4. 2.65 A crystal structure of mouse TB-RBP
    Title: Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenosine deaminase domain-containing protein 1
Names
adenosine deaminase domain containing 1 (testis specific)
testis nuclear RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009350.3 → NP_033376.2  adenosine deaminase domain-containing protein 1

    See identical proteins and their annotated locations for NP_033376.2

    Status: VALIDATED

    Source sequence(s)
    AL662823
    Consensus CDS
    CCDS17315.1
    UniProtKB/Swiss-Prot
    A2AAD7, A2AAD8, A2AAV1, Q08EL2, Q3V0N7, Q5SUE7, Q62309, Q9JLB6
    UniProtKB/TrEMBL
    F8WI80
    Related
    ENSMUSP00000115260.2, ENSMUST00000144629.8
    Conserved Domains (2) summary
    smart00358
    Location:139 → 204
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:246 → 618
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    37117805..37165661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SUE7.1 GenPept UniProtKB/Swiss-Prot:Q5SUE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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