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Morf4l1 mortality factor 4 like 1 [ Mus musculus (house mouse) ]

Gene ID: 21761, updated on 16-Oct-2021

Summary

Official Symbol
Morf4l1provided by MGI
Official Full Name
mortality factor 4 like 1provided by MGI
Primary source
MGI:MGI:1096551
See related
Ensembl:ENSMUSG00000062270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRG15; Tex189; TEG-189; MORFRG15; mKIAA4002
Expression
Broad expression in testis adult (RPKM 222.1), CNS E11.5 (RPKM 158.1) and 24 other tissues See more
Orthologs
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Genomic context

See Morf4l1 in Genome Data Viewer
Location:
9; 9 E3.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89973722..89996873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90091669..90114820, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (89986507..90009658, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thymidine kinase 1 pseudogene Neighboring gene cathepsin H Neighboring gene transmembrane protein 41B, pseudogene Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • KIAA4002, MGC102415, MGC103105, MGC118047

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H2A acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mortality factor 4-like protein 1
Names
MORF-related gene 15 protein
testis expressed gene 189
testis-expressed gene 189 protein
transcription factor-like protein MRG15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039147.2NP_001034236.1  mortality factor 4-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001034236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC140392, BC085103
    Consensus CDS
    CCDS23400.1
    UniProtKB/Swiss-Prot
    P60762
    Related
    ENSMUSP00000082346.6, ENSMUST00000085248.12
    Conserved Domains (2) summary
    cd18983
    Location:15110
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:184351
    MRG
  2. NM_001357780.1NP_001344709.1  mortality factor 4-like protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC140392
    Conserved Domains (2) summary
    cd18983
    Location:15109
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:183350
    MRG
  3. NM_024431.3NP_077751.1  mortality factor 4-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_077751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC140392, AK167079, BC085103
    Consensus CDS
    CCDS52885.1
    UniProtKB/Swiss-Prot
    P60762
    UniProtKB/TrEMBL
    Q569V4
    Related
    ENSMUSP00000132020.2, ENSMUST00000169860.8
    Conserved Domains (2) summary
    cd18983
    Location:1571
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:145312
    MRG

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    89973722..89996873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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