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Rin3 Ras and Rab interactor 3 [ Mus musculus (house mouse) ]

Gene ID: 217835, updated on 5-Mar-2024

Summary

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Official Symbol
Rin3provided by MGI
Official Full Name
Ras and Rab interactor 3provided by MGI
Primary source
MGI:MGI:2385708
See related
Ensembl:ENSMUSG00000044456 AllianceGenome:MGI:2385708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430500K07
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 24.0), lung adult (RPKM 16.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rin3 in Genome Data Viewer
Location:
12 E; 12 51.45 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102248572..102358982)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102282840..102390854)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene STARR-seq mESC enhancer starr_33096 Neighboring gene STARR-positive B cell enhancer ABC_E1862 Neighboring gene legumain Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene predicted gene, 30198

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Shen R, et al. Transl Neurodegener, 2020 Jun 18. PMID 32552912, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
    Title: Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of negative regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of vesicle size ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras and Rab interactor 3
Names
Ras interaction/interference protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161365.1 → NP_001154837.1  ras and Rab interactor 3 isoform 2

    See identical proteins and their annotated locations for NP_001154837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC122302, AC139330
    Consensus CDS
    CCDS49145.1
    UniProtKB/TrEMBL
    Q3U332, Q3U3Y6, Q80WA0
    Related
    ENSMUSP00000122646.2, ENSMUST00000133820.2
    Conserved Domains (3) summary
    pfam02204
    Location:657 → 759
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl00155
    Location:808 → 878
    UBQ; Ubiquitin-like proteins
    cl15255
    Location:1 → 73
    SH2; Src homology 2 (SH2) domain

  2. NM_177620.4 → NP_808288.2  ras and Rab interactor 3 isoform 1

    See identical proteins and their annotated locations for NP_808288.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139330, BC058432, BC137907
    Consensus CDS
    CCDS26118.1
    UniProtKB/Swiss-Prot
    B2RQF8, P59729
    UniProtKB/TrEMBL
    Q3U3Y6
    Related
    ENSMUSP00000060771.8, ENSMUST00000056950.14
    Conserved Domains (3) summary
    cd10395
    Location:52 → 153
    SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
    pfam02204
    Location:737 → 839
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl00155
    Location:888 → 958
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102248572..102358982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246670.2 → XP_030102530.1  ras and Rab interactor 3 isoform X2

    Conserved Domains (2) summary
    pfam02204
    Location:406 → 509
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl28922
    Location:544 → 631
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_036157343.1 → XP_036013236.1  ras and Rab interactor 3 isoform X1

  3. XM_030246671.2 → XP_030102531.1  ras and Rab interactor 3 isoform X2

    Conserved Domains (2) summary
    pfam02204
    Location:406 → 509
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl28922
    Location:544 → 631
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59729.2 GenPept UniProtKB/Swiss-Prot:P59729

Gene LinkOut

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