Tgfa transforming growth factor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgfaprovided by MGI
Official Full Name: transforming growth factor alphaprovided by MGI
Primary source: MGI:MGI:98724
See related: Ensembl:ENSMUSG00000029999 AllianceGenome:MGI:98724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: wa1; wa-1
Summary: This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in ovary adult (RPKM 6.7), CNS E18 (RPKM 6.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.62 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86172020..86252726)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86195038..86275744)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Excess Transforming Growth Factor-alpha Changed the Cell Properties of Corneal Epithelium and Stroma.
Title: Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma.
TGFalpha preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.
Title: TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.
Tgfa null mice are equally susceptible to spontaneous osteoarthritis development during aging.
Title: Context-specific protection of TGFα null mice from osteoarthritis.
Here the authors show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles.
Title: Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.
TGF-alpha contributes to the progression of diabetic kidney disease.
Title: Role of TGF-alpha in the progression of diabetic kidney disease.
Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma.
Title: Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.
c-Myc and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin in transgenic mice.
Title: c-Myc and transforming growth factor α enhance the development of hepatic lesions due to mutant β-catenin in transgenic mice.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
Title: FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium.
findings suggest that elevated PHD4 levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha
Title: PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
Title: Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2)
Targeted (2) 1 citation

General gene information

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Markers

Tgfa (e-PCR), detects polymorphism
- UniSTS:472900

stSG633446 (e-PCR)
- UniSTS:460101

Tgfa (e-PCR), detects polymorphism
- UniSTS:463966

Tgfa (e-PCR), detects polymorphism
- UniSTS:144607

Tgfa (e-PCR), detects polymorphism
- UniSTS:144608

Tgfa (e-PCR), detects polymorphism
- UniSTS:233971

Tgfa (e-PCR), detects polymorphism
- UniSTS:516088

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IPI Inferred from Physical Interaction more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protransforming growth factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403118.1 → NP_001390047.1 protransforming growth factor alpha isoform 2 preproprotein

Status: REVIEWED

Source sequence(s)

AC159549
NM_031199.5 → NP_112476.1 protransforming growth factor alpha isoform 1 preproprotein

See identical proteins and their annotated locations for NP_112476.1

Status: REVIEWED

Source sequence(s)

AC159549

Consensus CDS

CCDS51832.1

UniProtKB/Swiss-Prot

P48030

UniProtKB/TrEMBL

Q545E4

Related

ENSMUSP00000032066.10, ENSMUST00000032066.13

Conserved Domains (2) summary

PHA02887
Location:43 → 82

PHA02887; EGF-like protein; Provisional

PHA03099
Location:46 → 120

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

86172020..86252726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255312.1 → XP_030111172.1 protransforming growth factor alpha isoform X1

Conserved Domains (2) summary

PHA02887
Location:43 → 82

PHA02887; EGF-like protein; Provisional

PHA03099
Location:46 → 120

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional