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Pou6f2 POU domain, class 6, transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 218030, updated on 5-Mar-2024

Summary

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Official Symbol
Pou6f2provided by MGI
Official Full Name
POU domain, class 6, transcription factor 2provided by MGI
Primary source
MGI:MGI:2443631
See related
Ensembl:ENSMUSG00000009734 AllianceGenome:MGI:2443631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPF-1; D130006K24Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; eye; and reproductive system. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F2 (POU class 6 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.0), whole brain E14.5 (RPKM 0.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Pou6f2 in Genome Data Viewer
Location:
13 A2; 13 6.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (18295683..18797703, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (18124960..18382044, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33768 Neighboring gene RIKEN cDNA 4930448F12 gene Neighboring gene ZW10 interactor pseudogene Neighboring gene predicted gene, 31832 Neighboring gene predicted gene, 46402 Neighboring gene STARR-seq mESC enhancer starr_33769 Neighboring gene STARR-seq mESC enhancer starr_33770 Neighboring gene STARR-seq mESC enhancer starr_33771 Neighboring gene STARR-seq mESC enhancer starr_33773 Neighboring gene STARR-seq mESC enhancer starr_33776 Neighboring gene STARR-seq mESC enhancer starr_33777 Neighboring gene VPS41 HOPS complex subunit Neighboring gene STARR-seq mESC enhancer starr_33781 Neighboring gene STARR-seq mESC enhancer starr_33782 Neighboring gene STARR-seq mESC enhancer starr_33784 Neighboring gene predicted gene, 26172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. Perotti D, et al. Genes Chromosomes Cancer, 2001 May. PMID 11284034
  2. The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. Di Renzo F, et al. J Pediatr Hematol Oncol, 2006 Dec. PMID 17164647
  3. Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Xiang M. Dev Biol, 1998 May 15. PMID 9630743
  4. Math5 determines the competence state of retinal ganglion cell progenitors. Yang Z, et al. Dev Biol, 2003 Dec 1. PMID 14623245
  5. Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. King R, et al. PLoS Genet, 2018 Jan. PMID 29370175, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
POU domain, class 6, transcription factor 2
Names
retina-derived POU-domain factor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175006.3 → NP_778171.2  POU domain, class 6, transcription factor 2

    Status: VALIDATED

    Source sequence(s)
    AC154207, AC154356, AC154628, LXEJ02011613
    UniProtKB/TrEMBL
    B2RQZ8
    Related
    ENSMUSP00000139282.2, ENSMUST00000175703.9
    Conserved Domains (2) summary
    pfam00046
    Location:610 → 664
    Homeobox; Homeobox domain
    cl22952
    Location:477 → 586
    Pou; Pou domain - N-terminal to homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    18295683..18797703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157977.1 → XP_036013870.1  POU domain, class 6, transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    B2RQZ8
    Conserved Domains (2) summary
    pfam00046
    Location:647 → 701
    Homeobox; Homeobox domain
    cl22952
    Location:514 → 623
    Pou; Pou domain - N-terminal to homeobox domain

  2. XM_036157978.1 → XP_036013871.1  POU domain, class 6, transcription factor 2 isoform X2

    UniProtKB/TrEMBL
    B2RQZ8
    Conserved Domains (2) summary
    pfam00046
    Location:611 → 665
    Homeobox; Homeobox domain
    cl22952
    Location:514 → 587
    Pou; Pou domain - N-terminal to homeobox domain

  3. XM_036157981.1 → XP_036013874.1  POU domain, class 6, transcription factor 2 isoform X4

    UniProtKB/TrEMBL
    B2RQZ8
    Conserved Domains (2) summary
    pfam00046
    Location:600 → 654
    Homeobox; Homeobox domain
    cl22952
    Location:467 → 576
    Pou; Pou domain - N-terminal to homeobox domain

  4. XM_036157982.1 → XP_036013875.1  POU domain, class 6, transcription factor 2 isoform X5

  5. XM_036157980.1 → XP_036013873.1  POU domain, class 6, transcription factor 2 isoform X3

    UniProtKB/TrEMBL
    B2RQZ8
    Related
    ENSMUSP00000114173.3, ENSMUST00000139064.10
    Conserved Domains (2) summary
    pfam00046
    Location:610 → 664
    Homeobox; Homeobox domain
    cl22952
    Location:477 → 586
    Pou; Pou domain - N-terminal to homeobox domain

  6. XM_036157979.1 → XP_036013872.1  POU domain, class 6, transcription factor 2 isoform X3

    UniProtKB/TrEMBL
    B2RQZ8
    Conserved Domains (2) summary
    pfam00046
    Location:610 → 664
    Homeobox; Homeobox domain
    cl22952
    Location:477 → 586
    Pou; Pou domain - N-terminal to homeobox domain

  7. XM_036157983.1 → XP_036013876.1  POU domain, class 6, transcription factor 2 isoform X6

RNA

  1. XR_004938015.1 RNA Sequence

  2. XR_004938014.1 RNA Sequence

  3. XR_004938016.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJI4.1 GenPept UniProtKB/Swiss-Prot:Q8BJI4

Gene LinkOut

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