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Gmds GDP-mannose 4, 6-dehydratase [ Mus musculus (house mouse) ]

Gene ID: 218138, updated on 5-Jan-2022

Summary

Official Symbol
Gmdsprovided by MGI
Official Full Name
GDP-mannose 4, 6-dehydrataseprovided by MGI
Primary source
MGI:MGI:1891112
See related
Ensembl:ENSMUSG00000038372
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C87208; BC031788
Summary
Predicted to enable GDP-mannose 4,6-dehydratase activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process and GDP-mannose metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in large intestine adult (RPKM 98.5), colon adult (RPKM 91.5) and 10 other tissues See more
Orthologs
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Genomic context

See Gmds in Genome Data Viewer
Location:
13; 13 A3.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32003566..32522744, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (31819583..32338762, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (31911455..32430413, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11379 Neighboring gene forkhead box C1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene predicted gene, 52056 Neighboring gene predicted gene, 35732 Neighboring gene predicted gene, 35672 Neighboring gene predicted gene, 52055 Neighboring gene predicted gene, 40876 Neighboring gene myosin light chain kinase family, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18773, MGC103045

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-mannose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in GDP-mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GDP-mannose 4,6 dehydratase
Names
GDP-D-mannose dehydratase
GMD
NP_666153.1
XP_006516719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146041.2NP_666153.1  GDP-mannose 4,6 dehydratase

    See identical proteins and their annotated locations for NP_666153.1

    Status: PROVISIONAL

    Source sequence(s)
    AL645643, AL645664, AL645697, AL645763, AL645783
    Consensus CDS
    CCDS26426.1
    UniProtKB/Swiss-Prot
    Q8K0C9
    Related
    ENSMUSP00000036696.8, ENSMUST00000041859.9
    Conserved Domains (2) summary
    TIGR01472
    Location:24366
    gmd; GDP-mannose 4,6-dehydratase
    pfam16363
    Location:27358
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    32003566..32522744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516656.4XP_006516719.1  GDP-mannose 4,6 dehydratase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:34285
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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