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Tgm2 transglutaminase 2, C polypeptide [ Mus musculus (house mouse) ]

Gene ID: 21817, updated on 17-Oct-2021

Summary

Official Symbol
Tgm2provided by MGI
Official Full Name
transglutaminase 2, C polypeptideprovided by MGI
Primary source
MGI:MGI:98731
See related
Ensembl:ENSMUSG00000037820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TG2; tTG; G[a]h; tTGas; TGase2
Expression
Broad expression in mammary gland adult (RPKM 134.3), lung adult (RPKM 130.8) and 19 other tissues See more
Orthologs
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Genomic context

See Tgm2 in Genome Data Viewer
Location:
2 H1; 2 78.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157958325..157988312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158116405..158146392, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (157942141..157972128, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene RIKEN cDNA 2010009K17 gene Neighboring gene predicted gene, 34458 Neighboring gene RIKEN cDNA D630003M21 gene Neighboring gene RIKEN cDNA 1700060C20 gene Neighboring gene predicted gene, 34514

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables histone dopaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone serotonyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide histaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-glutamine gamma-glutamyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-glutamine glutaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables transaminase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to serotonin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide cross-linking TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deamination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within salivary gland cavitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein-glutamine gamma-glutamyltransferase 2
Names
C polypeptide
TG(C)
TGC
TGase C
TGase II
TGase-2
isopeptidase TGM2
protein-glutamine deamidase TGM2
protein-glutamine dopaminyltransferase TGM2
protein-glutamine histaminyltransferase TGM2
protein-glutamine noradrenalinyltransferase TGM2
protein-glutamine serotonyltransferase TGM2
protein-glutamine-gamma-glutamyltransferase
tissue transglutaminase
transglutaminase C
transglutaminase II
transglutaminase-2
NP_033399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009373.3NP_033399.1  protein-glutamine gamma-glutamyltransferase 2

    See identical proteins and their annotated locations for NP_033399.1

    Status: PROVISIONAL

    Source sequence(s)
    AL669824
    Consensus CDS
    CCDS16985.1
    UniProtKB/Swiss-Prot
    P21981
    Related
    ENSMUSP00000099411.4, ENSMUST00000103122.10
    Conserved Domains (4) summary
    smart00460
    Location:269361
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:273369
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:7120
    Transglut_N; Transglutaminase family
    pfam00927
    Location:473572
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157958325..157988312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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