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Thy1 thymus cell antigen 1, theta [ Mus musculus (house mouse) ]

Gene ID: 21838, updated on 23-Jun-2021

Summary

Official Symbol
Thy1provided by MGI
Official Full Name
thymus cell antigen 1, thetaprovided by MGI
Primary source
MGI:MGI:98747
See related
Ensembl:ENSMUSG00000032011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T25; CD90; Thy-1; Thy1.1; Thy1.2; Thy-1.2
Summary
This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]
Expression
Biased expression in thymus adult (RPKM 668.7), cortex adult (RPKM 206.5) and 6 other tissues See more
Orthologs
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Genomic context

See Thy1 in Genome Data Viewer
Location:
9 A5.1; 9 24.52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (43954681..43959876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44043384..44048579)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (43851467..43856662)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30373 Neighboring gene predicted gene, 39323 Neighboring gene predicted gene, 39325 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene predicted gene, 38444

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GPI anchor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GPI anchor binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal cone cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinal cone cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in anchored component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thy-1 membrane glycoprotein
Names
thy-1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009382.3NP_033408.1  thy-1 membrane glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_033408.1

    Status: REVIEWED

    Source sequence(s)
    AC126459, AK003006, BF455369, CD776453, CJ043838
    Consensus CDS
    CCDS23093.1
    UniProtKB/Swiss-Prot
    P01831
    Related
    ENSMUSP00000110489.2, ENSMUST00000114840.2
    Conserved Domains (2) summary
    smart00406
    Location:33106
    IGv; Immunoglobulin V-Type
    smart00410
    Location:30111
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    43954681..43959876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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