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Wdr41 WD repeat domain 41 [ Mus musculus (house mouse) ]

Gene ID: 218460, updated on 25-Nov-2021

Summary

Official Symbol
Wdr41provided by MGI
Official Full Name
WD repeat domain 41provided by MGI
Primary source
MGI:MGI:2445123
See related
Ensembl:ENSMUSG00000042015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSTP048; B830029I03Rik
Summary
This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.7), cerebellum adult (RPKM 6.6) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr41 in Genome Data Viewer
Location:
13; 13 C3- D1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95112226..95161800)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94976329..95023316)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (95746303..95793269)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tubulin cofactor A Neighboring gene orthopedia homeobox Neighboring gene predicted gene, 41024 Neighboring gene predicted gene, 48350 Neighboring gene phosphodiesterase 8B Neighboring gene predicted gene, 41025 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene zinc finger, BED type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat-containing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032910.1 

    Range
    501..47473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_172590.4NP_766178.2  WD repeat-containing protein 41

    See identical proteins and their annotated locations for NP_766178.2

    Status: VALIDATED

    Source sequence(s)
    AK046853, AK082348, AK149993, BM943554, BQ043504
    Consensus CDS
    CCDS56896.2
    UniProtKB/Swiss-Prot
    Q3UDP0
    Related
    ENSMUSP00000124033.2, ENSMUST00000160801.8
    Conserved Domains (2) summary
    sd00039
    Location:87133
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:38350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95112226..95161800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158015.1XP_036013908.1  WD repeat-containing protein 41 isoform X1

    Related
    ENSMUSP00000055145.8, ENSMUST00000056512.14
    Conserved Domains (2) summary
    sd00039
    Location:87133
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:38350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006517584.4XP_006517647.1  WD repeat-containing protein 41 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:98154
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:87304
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004938023.1 RNA Sequence

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