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Pde8b phosphodiesterase 8B [ Mus musculus (house mouse) ]

Gene ID: 218461, updated on 14-Aug-2021

Summary

Official Symbol
Pde8bprovided by MGI
Official Full Name
phosphodiesterase 8Bprovided by MGI
Primary source
MGI:MGI:2443999
See related
Ensembl:ENSMUSG00000021684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230331L10Rik; C030047E14Rik
Expression
Biased expression in adrenal adult (RPKM 17.9), cortex adult (RPKM 8.4) and 9 other tissues See more
Orthologs
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Genomic context

See Pde8b in Genome Data Viewer
Location:
13; 13 D1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95160613..95386904, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95024105..95250401, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (95794060..96020259, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41024 Neighboring gene WD repeat domain 41 Neighboring gene predicted gene, 48350 Neighboring gene predicted gene, 41025 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene predicted gene, 22661 Neighboring gene zinc finger, BED type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
cell proliferation-inducing gene 22 protein
NP_001164140.1
NP_001333711.1
NP_001360932.1
NP_001360933.1
NP_001360934.1
NP_001360935.1
NP_001360936.1
NP_758467.2
XP_006517650.1
XP_006517651.1
XP_006517652.1
XP_006517654.1
XP_006517657.1
XP_011242951.1
XP_011242952.1
XP_011242953.1
XP_017170982.1
XP_017170983.1
XP_030103093.1
XP_030103094.1
XP_030103095.1
XP_030103096.1
XP_036013910.1
XP_036013911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170669.1NP_001164140.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK045991, BG695121
    Consensus CDS
    CCDS49331.1
    UniProtKB/TrEMBL
    E9PYP0
    Related
    ENSMUSP00000124068.2, ENSMUST00000162292.8
    Conserved Domains (3) summary
    PHA02597
    Location:158311
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:517764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
  2. NM_001346782.1NP_001333711.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Consensus CDS
    CCDS84052.1
    UniProtKB/TrEMBL
    E9PX38
    Related
    ENSMUSP00000124704.2, ENSMUST00000162153.9
  3. NM_001374003.1NP_001360932.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Related
    ENSMUSP00000128987.2, ENSMUST00000172104.8
    Conserved Domains (4) summary
    COG2202
    Location:167375
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:614861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280377
    PAS_9; PAS domain
  4. NM_001374004.1NP_001360933.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Related
    ENSMUSP00000070465.8, ENSMUST00000067082.14
    Conserved Domains (4) summary
    COG2202
    Location:166374
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613860
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279376
    PAS_9; PAS domain
  5. NM_001374005.1NP_001360934.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Conserved Domains (2) summary
    PHA02597
    Location:54207
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:413660
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. NM_001374006.1NP_001360935.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Conserved Domains (2) summary
    PHA02597
    Location:53206
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:412659
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. NM_001374007.1NP_001360936.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Conserved Domains (3) summary
    COG2202
    Location:63274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:510757
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:176273
    PAS_9; PAS domain
  8. NM_172263.2NP_758467.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK083166, BE860708, BG695121, BY244338, CD806392
    Consensus CDS
    CCDS49332.1
    UniProtKB/TrEMBL
    E9PXX4, Q8BI47
    Related
    ENSMUSP00000124409.2, ENSMUST00000162412.8
    Conserved Domains (4) summary
    smart00091
    Location:168212
    PAS; PAS domain
    COG2202
    Location:62212
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:459706
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:174227
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95160613..95386904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247236.2XP_030103096.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  2. XM_030247233.2XP_030103093.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    Conserved Domains (3) summary
    COG2202
    Location:87295
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:534781
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:200297
    PAS_9; PAS domain
  3. XM_036158017.1XP_036013910.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

    Conserved Domains (1) summary
    pfam00233
    Location:383630
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_011244649.4XP_011242951.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    See identical proteins and their annotated locations for XP_011242951.1

    Conserved Domains (3) summary
    COG2202
    Location:43254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  5. XM_006517594.5XP_006517657.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    See identical proteins and their annotated locations for XP_006517657.1

    Conserved Domains (3) summary
    COG2202
    Location:43254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  6. XM_030247235.2XP_030103095.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  7. XM_011244650.4XP_011242952.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  8. XM_030247234.2XP_030103094.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    Conserved Domains (3) summary
    PHA02597
    Location:157310
    30.2; hypothetical protein; Provisional
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:516763
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  9. XM_006517591.5XP_006517654.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    Conserved Domains (3) summary
    COG2202
    Location:86294
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:533780
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:199296
    PAS_9; PAS domain
  10. XM_036158018.1XP_036013911.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

    Conserved Domains (2) summary
    pfam00233
    Location:376623
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:42139
    PAS_9; PAS domain
  11. XM_017315494.3XP_017170983.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X12

    Conserved Domains (2) summary
    pfam00233
    Location:326573
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:4295
    PAS_9; PAS domain
  12. XM_011244651.4XP_011242953.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

    Conserved Domains (2) summary
    pfam00233
    Location:376623
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:42139
    PAS_9; PAS domain
  13. XM_017315493.3XP_017170982.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

    Conserved Domains (2) summary
    PHA02597
    Location:34187
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:393640
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  14. XM_006517588.5XP_006517651.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    Conserved Domains (2) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:566813
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  15. XM_006517587.5XP_006517650.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/TrEMBL
    E9Q8J6
    Related
    ENSMUSP00000022192.6, ENSMUST00000022192.12
    Conserved Domains (2) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:567814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  16. XM_006517589.5XP_006517652.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    Conserved Domains (4) summary
    COG2202
    Location:167317
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:564811
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280333
    PAS_9; PAS domain
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