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Marveld2 MARVEL (membrane-associating) domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 218518, updated on 25-Nov-2021

Summary

Official Symbol
Marveld2provided by MGI
Official Full Name
MARVEL (membrane-associating) domain containing 2provided by MGI
Primary source
MGI:MGI:2446166
See related
Ensembl:ENSMUSG00000021636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tric; Trica; Tricb; Tricc; MARVD2; Mrvldc2; BC003296
Expression
Broad expression in large intestine adult (RPKM 10.0), colon adult (RPKM 8.9) and 23 other tissues See more
Orthologs
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Genomic context

See Marveld2 in Genome Data Viewer
Location:
13; 13 D1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100732465..100753479, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100595957..100616971, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (101365912..101386926, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene occludin Neighboring gene small nucleolar RNA SNORA48 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene predicted gene, 24261 Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC55067

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in paranodal junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in tricellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tricellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in tricellular tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MARVEL domain-containing protein 2
Names
tricellulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038602.4NP_001033691.1  MARVEL domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001033691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC165159, AK133741
    Consensus CDS
    CCDS26732.1
    UniProtKB/Swiss-Prot
    Q3UZP0
    UniProtKB/TrEMBL
    A1BQX3
    Related
    ENSMUSP00000022137.8, ENSMUST00000022137.14
    Conserved Domains (2) summary
    pfam01284
    Location:182358
    MARVEL; Membrane-associating domain
    pfam07303
    Location:443545
    Occludin_ELL; Occludin homology domain
  2. NM_178410.3NP_848497.2  MARVEL domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC165159
    Consensus CDS
    CCDS49345.1
    UniProtKB/TrEMBL
    E9Q1T5
    Related
    ENSMUSP00000129990.2, ENSMUST00000163163.9
    Conserved Domains (1) summary
    pfam07303
    Location:169267
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100732465..100753479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517605.2XP_006517668.1  MARVEL domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006517668.1

    UniProtKB/Swiss-Prot
    Q3UZP0
    UniProtKB/TrEMBL
    A1BQX3
    Related
    ENSMUSP00000153294.2, ENSMUST00000225754.2
    Conserved Domains (2) summary
    pfam01284
    Location:182358
    MARVEL; Membrane-associating domain
    pfam07303
    Location:443545
    Occludin_ELL; Occludin homology domain
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