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Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 [ Mus musculus (house mouse) ]

Gene ID: 218756, updated on 22-Nov-2021

Summary

Official Symbol
Slc4a7provided by MGI
Official Full Name
solute carrier family 4, sodium bicarbonate cotransporter, member 7provided by MGI
Primary source
MGI:MGI:2443878
See related
Ensembl:ENSMUSG00000021733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NBC3; NBCn1; NBCn1-G; E430014N10Rik; Tg(Thy1-SNCA)12Mjff
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 6.9), CNS E14 (RPKM 6.6) and 27 other tissues See more
Orthologs
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Genomic context

See Slc4a7 in Genome Data Viewer
Location:
14; 14 A1
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7669819..7766808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14703011..14799944)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (15535539..15632457)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18142 Neighboring gene predicted gene, 46441 Neighboring gene NIMA (never in mitosis gene a)- related kinase 10 Neighboring gene predicted gene, 52165 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • C330023F04, E430014N10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic anion exchanger activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in auditory receptor cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cochlear nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium bicarbonate cotransporter 3
Names
Na-bicarbonate cotransporter
sodium bicarbonate cotransporter NBCn1-A
sodium bicarbonate cotransporter NBCn1-B
sodium bicarbonate cotransporter NBCn1-D
sodium bicarbonate cotransporter NBCn1-H
sodium bicarbonate cotransporter NBCn1-c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033270.2NP_001028442.2  sodium bicarbonate cotransporter 3 isoform 11

    See identical proteins and their annotated locations for NP_001028442.2

    Status: VALIDATED

    Source sequence(s)
    AC129580, CT025538
    Consensus CDS
    CCDS36810.1
    UniProtKB/TrEMBL
    F8VQC9
    Related
    ENSMUSP00000058313.7, ENSMUST00000057015.8
    Conserved Domains (4) summary
    TIGR00834
    Location:1181016
    ae; anion exchange protein
    pfam00955
    Location:456969
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:146413
    Band_3_cyto; Band 3 cytoplasmic domain
    pfam10487
    Location:599667
    Nup188; Nucleoporin subcomplex protein binding to Pom34
  2. NM_001360504.1NP_001347433.1  sodium bicarbonate cotransporter 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JX254910
    Consensus CDS
    CCDS88573.1
    Related
    ENSMUSP00000153045.3, ENSMUST00000223761.3
    Conserved Domains (1) summary
    cl26877
    Location:1181139
    Band_3_cyto; Band 3 cytoplasmic domain
  3. NM_001360505.1NP_001347434.1  sodium bicarbonate cotransporter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JX254909
    Related
    ENSMUSP00000153180.3, ENSMUST00000223607.3
    Conserved Domains (1) summary
    cl26877
    Location:1181126
    Band_3_cyto; Band 3 cytoplasmic domain
  4. NM_001360506.1NP_001347435.1  sodium bicarbonate cotransporter 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JX254908
    Related
    ENSMUSP00000153084.3, ENSMUST00000223981.3
    Conserved Domains (1) summary
    cl26877
    Location:1181139
    Band_3_cyto; Band 3 cytoplasmic domain
  5. NM_001360508.1NP_001347437.1  sodium bicarbonate cotransporter 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, JX254912
    Related
    ENSMUSP00000153470.3, ENSMUST00000224333.3
    Conserved Domains (1) summary
    cl26877
    Location:1131134
    Band_3_cyto; Band 3 cytoplasmic domain
  6. NM_001360509.1NP_001347438.1  sodium bicarbonate cotransporter 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JX254911
    Consensus CDS
    CCDS88570.1
    Related
    ENSMUSP00000153166.3, ENSMUST00000225175.3
    Conserved Domains (1) summary
    cl26877
    Location:1181126
    Band_3_cyto; Band 3 cytoplasmic domain
  7. NM_001360510.1NP_001347439.1  sodium bicarbonate cotransporter 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, HM624051
    Consensus CDS
    CCDS88576.1
    Related
    ENSMUSP00000152950.3, ENSMUST00000224672.3
    Conserved Domains (1) summary
    cl26877
    Location:1131121
    Band_3_cyto; Band 3 cytoplasmic domain
  8. NM_001360511.1NP_001347440.1  sodium bicarbonate cotransporter 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JQ349031
    Consensus CDS
    CCDS88574.1
    Related
    ENSMUSP00000152984.3, ENSMUST00000225238.3
    Conserved Domains (1) summary
    cl26877
    Location:1181036
    Band_3_cyto; Band 3 cytoplasmic domain
  9. NM_001360512.1NP_001347441.1  sodium bicarbonate cotransporter 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, JQ347261
    Consensus CDS
    CCDS88579.1
    Related
    ENSMUSP00000153345.3, ENSMUST00000224952.3
    Conserved Domains (1) summary
    cl26877
    Location:1131031
    Band_3_cyto; Band 3 cytoplasmic domain
  10. NM_001360513.1NP_001347442.1  sodium bicarbonate cotransporter 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, JQ349032
    Consensus CDS
    CCDS88571.1
    Related
    ENSMUSP00000153690.3, ENSMUST00000225979.3
    Conserved Domains (1) summary
    cl26877
    Location:1181023
    Band_3_cyto; Band 3 cytoplasmic domain
  11. NM_001360514.1NP_001347443.1  sodium bicarbonate cotransporter 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, JQ349033
    Consensus CDS
    CCDS88577.1
    Related
    ENSMUSP00000153648.3, ENSMUST00000223695.3
    Conserved Domains (1) summary
    cl26877
    Location:1131018
    Band_3_cyto; Band 3 cytoplasmic domain
  12. NM_001360515.1NP_001347444.1  sodium bicarbonate cotransporter 3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, HM624050
    Consensus CDS
    CCDS88580.1
    Related
    ENSMUSP00000152933.3, ENSMUST00000223740.3
    Conserved Domains (1) summary
    cl26877
    Location:1131011
    Band_3_cyto; Band 3 cytoplasmic domain
  13. NM_001360516.1NP_001347445.1  sodium bicarbonate cotransporter 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, GU386352
    Consensus CDS
    CCDS88572.1
    Related
    ENSMUSP00000153597.3, ENSMUST00000225630.3
    Conserved Domains (1) summary
    cl26877
    Location:1181003
    Band_3_cyto; Band 3 cytoplasmic domain
  14. NM_001360517.1NP_001347446.1  sodium bicarbonate cotransporter 3 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC129580, AK153567, BP761907, CD541823, CO430686, GU386353
    Consensus CDS
    CCDS88575.1
    Related
    ENSMUSP00000153323.3, ENSMUST00000226079.3
    Conserved Domains (1) summary
    cl26877
    Location:1181016
    Band_3_cyto; Band 3 cytoplasmic domain
  15. NM_001360520.1NP_001347449.1  sodium bicarbonate cotransporter 3 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC129580, BP761907, CD541823, CO430686, CT025538, JQ344322
    Consensus CDS
    CCDS88578.1
    Related
    ENSMUSP00000153093.3, ENSMUST00000224049.3
    Conserved Domains (1) summary
    cl26877
    Location:113998
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    7669819..7766808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315953.2XP_017171442.1  sodium bicarbonate cotransporter 3 isoform X3

    Conserved Domains (1) summary
    cl26877
    Location:1181159
    Band_3_cyto; Band 3 cytoplasmic domain
  2. XM_006517998.2XP_006518061.1  sodium bicarbonate cotransporter 3 isoform X1

    Conserved Domains (1) summary
    cl26877
    Location:1181159
    Band_3_cyto; Band 3 cytoplasmic domain
  3. XM_017315955.3XP_017171444.1  sodium bicarbonate cotransporter 3 isoform X4

    UniProtKB/TrEMBL
    U3RF68
    Related
    ENSMUSP00000153185.3, ENSMUST00000224752.3
    Conserved Domains (1) summary
    cl26877
    Location:1231131
    Band_3_cyto; Band 3 cytoplasmic domain
  4. XM_006517999.3XP_006518062.1  sodium bicarbonate cotransporter 3 isoform X2

    Conserved Domains (1) summary
    cl26877
    Location:1181146
    Band_3_cyto; Band 3 cytoplasmic domain

RNA

  1. XR_001781108.2 RNA Sequence

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