Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc4a7provided by MGI
Official Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7provided by MGI
Primary source: MGI:MGI:2443878
See related: Ensembl:ENSMUSG00000021733 AllianceGenome:MGI:2443878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NBC3; NBCn1; NBCn1-G; E430014N10Rik; Tg(Thy1-SNCA)12Mjff
Summary: Predicted to enable sodium:bicarbonate symporter activity. Acts upstream of or within cochlear nucleus development; sensory organ development; and visual perception. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is expressed in brain; metanephros; pancreas; and spiral ligament. Used to study Usher syndrome type 2C. Orthologous to human SLC4A7 (solute carrier family 4 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 6.9), CNS E14 (RPKM 6.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 7.08 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (7669819..7766808, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (14703011..14799944)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
Title: Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.
Title: Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.
Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice.
Title: Deletion of the Na/HCO(3) Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice.
Disruption of Slc4a10 results in loss of Slc4a7 expression specifically in inner ear fibrocytes but not in other tissues. At the ultrastructural level, mitochondria of spiral ligament knockout fibrocytes show severe alterations.
Title: Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.
NBCn1 regulates intracellular pH in ErbB2-induced breast cancer tissue by providing a pathway for cellular uptake of HCO3(-), which can neutralize metabolic acidic waste products
Title: Na(+),HCO(3)(-)-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice.
This study showed that extracellular acidification inhibits NBCn1 and NHE1 activity in VSMCs; NBCn1 is equivalently inhibited when pCO2 is raised or the bicarbonate level decreased. Lowering the sodium level inhibits NBCn1 and NHE1 markedly only below the typical physiological and pathophysiological range.
Title: Extracellular acidosis and very low [Na(+) ] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells.
Under physiological conditions NBCn1 bicarbonateuptake raises VSMC pHi and promotes filopodia, VSMC migration, and hypertrophic inward remodelling. Propose that axial pHi gradients enhance VSMC migration whereas global acidification inhibits VSMC proliferation and media hypertrophy after carotid artery ligation.
Title: Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling.
NBCn1 facilitates acid extrusion from breast cancer tissue, maintains the alkaline intracellular environment and promotes aggressive cancer development and growth
Title: Disrupting Na⁺, HCO₃⁻-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.
The electroneutral Na+-HCO3- cotransporter NBCn1 plays an essential role in murine duodenal acid-base balance and colonic mucus layer build-up in vivo
Title: Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo.
Slc4a7 is a major regulator of basal and FSK-stimulated duodenal HCO3 secretion
Title: The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Gene trapped (2) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc4a7 (e-PCR), detects polymorphism
- UniSTS:547124

AA892414 (e-PCR)
- UniSTS:249995

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:bicarbonate symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within auditory receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlear nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in phagosome acidification	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium bicarbonate cotransporter 3

Names: Na-bicarbonate cotransporter; sodium bicarbonate cotransporter NBCn1-A; sodium bicarbonate cotransporter NBCn1-B; sodium bicarbonate cotransporter NBCn1-D; sodium bicarbonate cotransporter NBCn1-H; sodium bicarbonate cotransporter NBCn1-c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033270.2 → NP_001028442.2 sodium bicarbonate cotransporter 3 isoform 11

See identical proteins and their annotated locations for NP_001028442.2

Status: VALIDATED

Source sequence(s)

AC129580, CT025538

Consensus CDS

CCDS36810.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

F8VQC9

Related

ENSMUSP00000058313.7, ENSMUST00000057015.8

Conserved Domains (4) summary

TIGR00834
Location:118 → 1016

ae; anion exchange protein

pfam00955
Location:456 → 969

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:146 → 413

Band_3_cyto; Band 3 cytoplasmic domain

pfam10487
Location:599 → 667

Nup188; Nucleoporin subcomplex protein binding to Pom34
NM_001360504.1 → NP_001347433.1 sodium bicarbonate cotransporter 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JX254910

Consensus CDS

CCDS88573.1

UniProtKB/TrEMBL

A0A286YCX2, A0A286YD14, J9RV59

Related

ENSMUSP00000153045.3, ENSMUST00000223761.3

Conserved Domains (1) summary

cl26877
Location:118 → 1139

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360505.1 → NP_001347434.1 sodium bicarbonate cotransporter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JX254909

UniProtKB/TrEMBL

A0A286YCX2, J9RZB2

Related

ENSMUSP00000153180.3, ENSMUST00000223607.3

Conserved Domains (1) summary

cl26877
Location:118 → 1126

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360506.1 → NP_001347435.1 sodium bicarbonate cotransporter 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JX254908

UniProtKB/TrEMBL

A0A286YD46, J9S4N6

Related

ENSMUSP00000153084.3, ENSMUST00000223981.3

Conserved Domains (1) summary

cl26877
Location:118 → 1139

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360508.1 → NP_001347437.1 sodium bicarbonate cotransporter 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, JX254912

UniProtKB/TrEMBL

A0A286YDK8, J9S7F7

Related

ENSMUSP00000153470.3, ENSMUST00000224333.3

Conserved Domains (1) summary

cl26877
Location:113 → 1134

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360509.1 → NP_001347438.1 sodium bicarbonate cotransporter 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JX254911

Consensus CDS

CCDS88570.1

UniProtKB/TrEMBL

A0A286YD46, A0A286YDA9, J9RDH0

Related

ENSMUSP00000153166.3, ENSMUST00000225175.3

Conserved Domains (1) summary

cl26877
Location:118 → 1126

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360510.1 → NP_001347439.1 sodium bicarbonate cotransporter 3 isoform 6

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, HM624051

Consensus CDS

CCDS88576.1

UniProtKB/TrEMBL

A0A286YCU2, A0A286YDK8, E3UVT9

Related

ENSMUSP00000152950.3, ENSMUST00000224672.3

Conserved Domains (1) summary

cl26877
Location:113 → 1121

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360511.1 → NP_001347440.1 sodium bicarbonate cotransporter 3 isoform 7

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JQ349031

Consensus CDS

CCDS88574.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

A0A286YCH3, I1VGT4

Related

ENSMUSP00000152984.3, ENSMUST00000225238.3

Conserved Domains (1) summary

cl26877
Location:118 → 1036

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360512.1 → NP_001347441.1 sodium bicarbonate cotransporter 3 isoform 8

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, JQ347261

Consensus CDS

CCDS88579.1

UniProtKB/TrEMBL

A0A286YDB4, H6WZF5, U3RKD2

Related

ENSMUSP00000153345.3, ENSMUST00000224952.3

Conserved Domains (1) summary

cl26877
Location:113 → 1031

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360513.1 → NP_001347442.1 sodium bicarbonate cotransporter 3 isoform 9

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, JQ349032

Consensus CDS

CCDS88571.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

A0A286YED8, I1VGT5

Related

ENSMUSP00000153690.3, ENSMUST00000225979.3

Conserved Domains (1) summary

cl26877
Location:118 → 1023

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360514.1 → NP_001347443.1 sodium bicarbonate cotransporter 3 isoform 10

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, JQ349033

Consensus CDS

CCDS88577.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

A0A286YDZ8, I1VGT6

Related

ENSMUSP00000153648.3, ENSMUST00000223695.3

Conserved Domains (1) summary

cl26877
Location:113 → 1018

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360515.1 → NP_001347444.1 sodium bicarbonate cotransporter 3 isoform 12

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, HM624050

Consensus CDS

CCDS88580.1

UniProtKB/TrEMBL

A0A286YCE1, E3UVT8, U3RKD2

Related

ENSMUSP00000152933.3, ENSMUST00000223740.3

Conserved Domains (1) summary

cl26877
Location:113 → 1011

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360516.1 → NP_001347445.1 sodium bicarbonate cotransporter 3 isoform 13

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, GU386352

Consensus CDS

CCDS88572.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

A0A286YDX4, D3Y272

Related

ENSMUSP00000153597.3, ENSMUST00000225630.3

Conserved Domains (1) summary

cl26877
Location:118 → 1003

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360517.1 → NP_001347446.1 sodium bicarbonate cotransporter 3 isoform 15

Status: VALIDATED

Source sequence(s)

AC129580, AK153567, BP761907, CD541823, CO430686, GU386353

Consensus CDS

CCDS88575.1

UniProtKB/TrEMBL

A0A286YD46, A0A286YD88, D3Y273

Related

ENSMUSP00000153323.3, ENSMUST00000226079.3

Conserved Domains (1) summary

cl26877
Location:118 → 1016

Band_3_cyto; Band 3 cytoplasmic domain
NM_001360520.1 → NP_001347449.1 sodium bicarbonate cotransporter 3 isoform 14

Status: VALIDATED

Source sequence(s)

AC129580, BP761907, CD541823, CO430686, CT025538, JQ344322

Consensus CDS

CCDS88578.1

UniProtKB/Swiss-Prot

Q3U5H7, Q8BTY2

UniProtKB/TrEMBL

A0A286YCQ1, H6WZ45

Related

ENSMUSP00000153093.3, ENSMUST00000224049.3

Conserved Domains (1) summary

cl26877
Location:113 → 998

Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

7669819..7766808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315953.2 → XP_017171442.1 sodium bicarbonate cotransporter 3 isoform X3

UniProtKB/TrEMBL

A0A286YD46

Conserved Domains (1) summary

cl26877
Location:118 → 1159

Band_3_cyto; Band 3 cytoplasmic domain
XM_006517998.2 → XP_006518061.1 sodium bicarbonate cotransporter 3 isoform X1

UniProtKB/TrEMBL

A0A286YCX2

Conserved Domains (1) summary

cl26877
Location:118 → 1159

Band_3_cyto; Band 3 cytoplasmic domain
XM_017315955.3 → XP_017171444.1 sodium bicarbonate cotransporter 3 isoform X4

UniProtKB/TrEMBL

A0A286YCX8, U3RF68

Related

ENSMUSP00000153185.3, ENSMUST00000224752.3

Conserved Domains (1) summary

cl26877
Location:123 → 1131

Band_3_cyto; Band 3 cytoplasmic domain
XM_006517999.3 → XP_006518062.1 sodium bicarbonate cotransporter 3 isoform X2

UniProtKB/TrEMBL

A0A286YCX2

Conserved Domains (1) summary

cl26877
Location:118 → 1146

Band_3_cyto; Band 3 cytoplasmic domain