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Tll1 tolloid-like [ Mus musculus (house mouse) ]

Gene ID: 21892, updated on 16-Oct-2021

Summary

Official Symbol
Tll1provided by MGI
Official Full Name
tolloid-likeprovided by MGI
Primary source
MGI:MGI:106923
See related
Ensembl:ENSMUSG00000053626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tll; Tll-1; b2b2476Clo
Expression
Biased expression in cerebellum adult (RPKM 2.0), limb E14.5 (RPKM 0.7) and 13 other tissues See more
Orthologs
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Genomic context

See Tll1 in Genome Data Viewer
Location:
8 B3.1; 8 32.19 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (64466132..64659042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64013098..64206008, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (66493567..66684790, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24580 Neighboring gene predicted gene, 35713 Neighboring gene shugoshin 2B Neighboring gene predicted gene, 53436 Neighboring gene predicted gene, 35472 Neighboring gene predicted gene, 35521

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tolloid-like protein 1
NP_033416.2
XP_006509377.1
XP_006509378.1
XP_011240487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009390.3NP_033416.2  tolloid-like protein 1 precursor

    See identical proteins and their annotated locations for NP_033416.2

    Status: VALIDATED

    Source sequence(s)
    AC110622, AC149051, AK080919, AK139103, CF734525
    Consensus CDS
    CCDS40352.1
    UniProtKB/TrEMBL
    G3X9F5
    Related
    ENSMUSP00000070560.5, ENSMUST00000066166.6
    Conserved Domains (4) summary
    cd04281
    Location:148347
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:462571
    CUB; CUB domain
    pfam01400
    Location:155348
    Astacin; Astacin (Peptidase family M12A)
    pfam14670
    Location:734769
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    64466132..64659042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509314.4XP_006509377.1  tolloid-like protein 1 isoform X1

    Conserved Domains (3) summary
    cd04281
    Location:99298
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:413522
    CUB; CUB domain
    pfam14670
    Location:685720
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_011242185.3XP_011240487.1  tolloid-like protein 1 isoform X2

    Conserved Domains (3) summary
    pfam00431
    Location:176285
    CUB; CUB domain
    pfam14670
    Location:448483
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00064
    Location:2061
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  3. XM_006509315.4XP_006509378.1  tolloid-like protein 1 isoform X3

    Conserved Domains (3) summary
    pfam00431
    Location:69178
    CUB; CUB domain
    pfam14670
    Location:341376
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00049
    Location:165
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
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