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Hmbox1 homeobox containing 1 [ Mus musculus (house mouse) ]

Gene ID: 219150, updated on 23-Jun-2021

Summary

Official Symbol
Hmbox1provided by MGI
Official Full Name
homeobox containing 1provided by MGI
Primary source
MGI:MGI:2445066
See related
Ensembl:ENSMUSG00000021972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI451877; AI604847; F830020C16Rik
Expression
Ubiquitous expression in lung adult (RPKM 16.3), thymus adult (RPKM 10.2) and 28 other tissues See more
Orthologs
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Genomic context

See Hmbox1 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65049049..65187354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64811600..64949899, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (65441055..65568684, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 13B Neighboring gene non-SMC element 2 homolog (MMS21, S. cerevisiae) pseudogene Neighboring gene predicted gene, 26225 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene integrator complex subunit 9 Neighboring gene predicted gene, 52118 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene predicted gene, 52119

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347626.1NP_001334555.1  homeobox-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132602, AC141425, AK052729, AW049636
    Consensus CDS
    CCDS84150.1
    UniProtKB/Swiss-Prot
    Q8BJA3
    UniProtKB/TrEMBL
    H3BKM3
    Related
    ENSMUSP00000135448.2, ENSMUST00000176128.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  2. NM_001347627.1NP_001334556.1  homeobox-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two alternate exons in its 3' coding region, including an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC132602, AC141425, AI604847, AK052729, CF737939
    Consensus CDS
    CCDS84149.1
    UniProtKB/Swiss-Prot
    Q8BJA3
    Related
    ENSMUSP00000022544.8, ENSMUST00000022544.14
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  3. NM_177338.6NP_796312.2  homeobox-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_796312.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa shorter than isoform 1.
    Source sequence(s)
    AC132602, AC141425, AK052729, AW049636
    Consensus CDS
    CCDS36955.1
    UniProtKB/Swiss-Prot
    Q8BJA3
    Related
    ENSMUSP00000066905.4, ENSMUST00000067843.10
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65049049..65187354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247768.2XP_030103628.1  homeobox-containing protein 1 isoform X9

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  2. XM_030247767.2XP_030103627.1  homeobox-containing protein 1 isoform X9

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  3. XM_011245031.4XP_011243333.1  homeobox-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  4. XM_011245029.4XP_011243331.1  homeobox-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  5. XM_011245036.4XP_011243338.1  homeobox-containing protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011243338.1

    UniProtKB/Swiss-Prot
    Q8BJA3
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  6. XM_011245035.4XP_011243337.1  homeobox-containing protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011243337.1

    UniProtKB/Swiss-Prot
    Q8BJA3
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  7. XM_030247765.2XP_030103625.1  homeobox-containing protein 1 isoform X2

    Related
    ENSMUSP00000135372.3, ENSMUST00000177326.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  8. XM_030247766.2XP_030103626.1  homeobox-containing protein 1 isoform X6

    Related
    ENSMUSP00000135272.2, ENSMUST00000175744.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  9. XM_011245037.4XP_011243339.1  homeobox-containing protein 1 isoform X10

    Related
    ENSMUSP00000135657.3, ENSMUST00000175905.8
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  10. XM_011245034.4XP_011243336.1  homeobox-containing protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011243336.1

    UniProtKB/Swiss-Prot
    Q8BJA3
    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  11. XM_006518882.5XP_006518945.1  homeobox-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  12. XM_011245033.4XP_011243335.1  homeobox-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011243335.1

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
  13. XM_036158568.1XP_036014461.1  homeobox-containing protein 1 isoform X8

    Conserved Domains (2) summary
    cd00086
    Location:268340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_004938387.1 RNA Sequence

  2. XR_004938386.1 RNA Sequence

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