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Top2a topoisomerase (DNA) II alpha [ Mus musculus (house mouse) ]

Gene ID: 21973, updated on 25-Jan-2022

Summary

Official Symbol
Top2aprovided by MGI
Official Full Name
topoisomerase (DNA) II alphaprovided by MGI
Primary source
MGI:MGI:98790
See related
Ensembl:ENSMUSG00000020914 AllianceGenome:MGI:98790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Top-2
Summary
Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 10 other tissues See more
Orthologs
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Genomic context

See Top2a in Genome Data Viewer
Location:
11 D; 11 62.91 cM
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98883773..98915037, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98992947..99024199, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98854261..98885503, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha Neighboring gene predicted gene, 22061 Neighboring gene gap junction protein, delta 3 Neighboring gene predicted gene, 23451 Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding, bending ISO
Inferred from Sequence Orthology
more info
 
enables DNA topoisomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA ligation ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA topological change ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female meiosis chromosome separation TAS
Traceable Author Statement
more info
PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with centriole ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA topoisomerase 2-alpha
Names
DNA Topoisomerase II alpha
DNA topoisomerase II, alpha isozyme
NP_035753.2
XP_006533216.1
XP_006533217.1
XP_006533218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011623.2NP_035753.2  DNA topoisomerase 2-alpha

    See identical proteins and their annotated locations for NP_035753.2

    Status: VALIDATED

    Source sequence(s)
    AL591067
    Consensus CDS
    CCDS25370.1
    UniProtKB/Swiss-Prot
    Q01320
    Related
    ENSMUSP00000068896.8, ENSMUST00000068031.8
    Conserved Domains (2) summary
    PTZ00108
    Location:241441
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam08070
    Location:14311517
    DTHCT; DTHCT (NUC029) region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98883773..98915037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533155.4XP_006533218.1  DNA topoisomerase 2-alpha isoform X2

    See identical proteins and their annotated locations for XP_006533218.1

    Conserved Domains (2) summary
    PTZ00108
    Location:241440
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam08070
    Location:14301516
    DTHCT; DTHCT (NUC029) region
  2. XM_006533153.4XP_006533216.1  DNA topoisomerase 2-alpha isoform X1

    See identical proteins and their annotated locations for XP_006533216.1

    UniProtKB/Swiss-Prot
    Q01320
    Conserved Domains (2) summary
    PTZ00108
    Location:241441
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam08070
    Location:14311517
    DTHCT; DTHCT (NUC029) region
  3. XM_006533154.4XP_006533217.1  DNA topoisomerase 2-alpha isoform X2

    See identical proteins and their annotated locations for XP_006533217.1

    Conserved Domains (2) summary
    PTZ00108
    Location:241440
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam08070
    Location:14301516
    DTHCT; DTHCT (NUC029) region
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