Tpm1 tropomyosin 1, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpm1provided by MGI
Official Full Name: tropomyosin 1, alphaprovided by MGI
Primary source: MGI:MGI:98809
See related: Ensembl:ENSMUSG00000032366 AllianceGenome:MGI:98809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TM2; Tm3; Tmpa; Tpm-1; alpha-TM; TPM1kappa
Summary: Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 766.9), heart adult (RPKM 589.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 36.27 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (66929872..66956954, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (67022590..67049672, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway.
Title: TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway.
Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
Title: Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF-kappaB signaling pathway in the retina of aged mice.
Title: Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF-κB signaling pathway in the retina of aged mice.
The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
Title: The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy.
Title: Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy.
Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.
Title: FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
The cMyBP-C hypertrophic cardiomyopathy variant L348P enhances thin filament activation through an increased shift in tropomyosin position.
Title: The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position.
three-dimensional structure of F-actin at a resolution of 3.7 A in complex with tropomyosin at a resolution of 6.5 A, determined by electron cryomicroscopy
Title: Structure of the F-actin-tropomyosin complex.
data also identify a novel alphaTM1/Tmod1-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis.
Title: Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.
This is the first study to demonstrate that decreasing phosphorylation of tropomyosin can rescue a hypertrophic cardiomyopathic phenotype.
Title: Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA986836 (e-PCR)
- UniSTS:165644

Tpm1 (e-PCR), detects polymorphism
- UniSTS:144664

RH140171 (e-PCR)
- UniSTS:222250

AI854628 (e-PCR)
- UniSTS:164408

NoName (e-PCR)
- UniSTS:236174

NoName (e-PCR)
- UniSTS:236176

RH126046 (e-PCR)
- UniSTS:162758

RH144195 (e-PCR)
- UniSTS:233441

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate by epinephrine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in ruffle organization	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of muscle thin filament tropomyosin	TAS Traceable Author Statement more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomyosin alpha-1 chain

Names: alpha-tropomyosin; tropomyosin 1 kappa; tropomyosin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164248.1 → NP_001157720.1 tropomyosin alpha-1 chain isoform Tpm1.1st

See identical proteins and their annotated locations for NP_001157720.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.1, also known as variant 1) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.1st) is the same length, but has an alternate C-terminus, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52845.1

UniProtKB/Swiss-Prot

P19354, P58771

UniProtKB/TrEMBL

Q545Y3

Related

ENSMUSP00000109315.4, ENSMUST00000113685.10

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001164249.1 → NP_001157721.1 tropomyosin alpha-1 chain isoform Tpm1.2st

See identical proteins and their annotated locations for NP_001157721.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.2, also known as variant 2) lacks an in-frame exon and has an alternate in-frame exon compared to variant Tpm1.6. The encoded isoform (Tpm1.2st) is the same length but has a short region of sequence differences, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52848.1

UniProtKB/TrEMBL

B7ZNL3

Related

ENSMUSP00000109335.2, ENSMUST00000113705.8

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001164250.1 → NP_001157722.1 tropomyosin alpha-1 chain isoform Tpm1.7cy

See identical proteins and their annotated locations for NP_001157722.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.7, also known as variant 4) lacks an exon and contains another alternate exon compared to variant Tpm1.6. The encoded isoform (Tpm1.7cy) is the same length but has short regions of sequence differences and an alternate C-terminus, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52846.1

UniProtKB/TrEMBL

E9Q450

Related

ENSMUSP00000109327.2, ENSMUST00000113697.8

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001164251.1 → NP_001157723.1 tropomyosin alpha-1 chain isoform Tpm1.5cy

See identical proteins and their annotated locations for NP_001157723.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.5, also known as variant 5) differs in the 3' UTR and coding sequence, lacks internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.5cy) is the same length but has short regions of sequence differences, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52847.1

UniProtKB/TrEMBL

Q8BP43

Related

ENSMUSP00000051888.10, ENSMUST00000050905.16

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001164252.1 → NP_001157724.1 tropomyosin alpha-1 chain isoform Tpm1.8cy

See identical proteins and their annotated locations for NP_001157724.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.8, also known as variant 6) differs in the 5' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.8cy) has an alternate N-terminus compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52841.1

UniProtKB/TrEMBL

G5E8R1

Related

ENSMUSP00000109325.2, ENSMUST00000113695.8

Conserved Domains (1) summary

pfam00261
Location:12 → 246

Tropomyosin
NM_001164253.1 → NP_001157725.1 tropomyosin alpha-1 chain isoform Tpm1.9cy

See identical proteins and their annotated locations for NP_001157725.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.9, also known as variant 7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.9cy) has an alternate N-terminus, has a short internal region of sequence differences and is shorter, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52843.1

UniProtKB/TrEMBL

G5E8R2

Related

ENSMUSP00000109326.2, ENSMUST00000113696.8

Conserved Domains (1) summary

pfam00261
Location:12 → 246

Tropomyosin
NM_001164254.1 → NP_001157726.1 tropomyosin alpha-1 chain isoform Tpm1.13

See identical proteins and their annotated locations for NP_001157726.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.13, also known as variant 8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The encoded isoform (Tpm1.13) has alternate N- and C- termini and is shorter, compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Conserved Domains (1) summary

pfam00261
Location:12 → 246

Tropomyosin
NM_001164255.1 → NP_001157727.1 tropomyosin alpha-1 chain isoform Tpm1.10br

See identical proteins and their annotated locations for NP_001157727.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.10, also known as variant 9) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52844.1

UniProtKB/TrEMBL

E9Q452

Related

ENSMUSP00000109323.2, ENSMUST00000113693.8

Conserved Domains (1) summary

pfam00261
Location:48 → 280

Tropomyosin
NM_001164256.1 → NP_001157728.1 tropomyosin alpha-1 chain isoform Tpm1.12br

See identical proteins and their annotated locations for NP_001157728.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.12, also known as variant 10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The resulting isoform (Tpm1.12br) has shorter and distinct N- and C-termini compared to isoform Tpm1.6cy.

Source sequence(s)

AC166370

Consensus CDS

CCDS52842.1

UniProtKB/TrEMBL

G5E8R0

Related

ENSMUSP00000109320.2, ENSMUST00000113690.8

Conserved Domains (1) summary

pfam00261
Location:12 → 244

Tropomyosin
NM_024427.4 → NP_077745.2 tropomyosin alpha-1 chain isoform Tpm1.6cy

See identical proteins and their annotated locations for NP_077745.2

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm1.6, also known as variant 3) represents one of the longest transcripts and encodes one of the longest isoforms (Tpm1.6cy).

Source sequence(s)

AC166370

Consensus CDS

CCDS23311.1

UniProtKB/TrEMBL

Q564G1

Related

ENSMUSP00000109337.3, ENSMUST00000113707.9

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin