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Tpm1 tropomyosin 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 22003, updated on 16-Oct-2021

Summary

Official Symbol
Tpm1provided by MGI
Official Full Name
tropomyosin 1, alphaprovided by MGI
Primary source
MGI:MGI:98809
See related
Ensembl:ENSMUSG00000032366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TM2; Tm3; Tmpa; Tpm-1; AA986836; AI854628; alpha-TM; TPM1kappa
Expression
Biased expression in bladder adult (RPKM 766.9), heart adult (RPKM 589.0) and 6 other tissues See more
Orthologs
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Genomic context

See Tpm1 in Genome Data Viewer
Location:
9 C; 9 36.27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66929872..66956954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (67022590..67049672, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (66870400..66897020, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene lactamase, beta Neighboring gene predicted gene, 30639 Neighboring gene VISTA enhancer mm100 Neighboring gene predicted gene 10646 Neighboring gene predicted gene, 22145 Neighboring gene predicted gene, 19299 Neighboring gene predicted gene, 40529

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament capping ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate by epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bleb ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tropomyosin alpha-1 chain
Names
alpha-tropomyosin
tropomyosin 1 kappa
tropomyosin-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164248.1NP_001157720.1  tropomyosin alpha-1 chain isoform Tpm1.1st

    See identical proteins and their annotated locations for NP_001157720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.1, also known as variant 1) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.1st) is the same length, but has an alternate C-terminus, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52845.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q545Y3
    Related
    ENSMUSP00000109315.4, ENSMUST00000113685.10
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  2. NM_001164249.1NP_001157721.1  tropomyosin alpha-1 chain isoform Tpm1.2st

    See identical proteins and their annotated locations for NP_001157721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.2, also known as variant 2) lacks an in-frame exon and has an alternate in-frame exon compared to variant Tpm1.6. The encoded isoform (Tpm1.2st) is the same length but has a short region of sequence differences, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52848.1
    UniProtKB/TrEMBL
    B7ZNL3
    Related
    ENSMUSP00000109335.2, ENSMUST00000113705.8
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  3. NM_001164250.1NP_001157722.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

    See identical proteins and their annotated locations for NP_001157722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.7, also known as variant 4) lacks an exon and contains another alternate exon compared to variant Tpm1.6. The encoded isoform (Tpm1.7cy) is the same length but has short regions of sequence differences and an alternate C-terminus, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52846.1
    UniProtKB/TrEMBL
    E9Q450
    Related
    ENSMUSP00000109327.2, ENSMUST00000113697.8
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  4. NM_001164251.1NP_001157723.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

    See identical proteins and their annotated locations for NP_001157723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.5, also known as variant 5) differs in the 3' UTR and coding sequence, lacks internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.5cy) is the same length but has short regions of sequence differences, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52847.1
    UniProtKB/TrEMBL
    Q8BP43
    Related
    ENSMUSP00000051888.10, ENSMUST00000050905.16
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  5. NM_001164252.1NP_001157724.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

    See identical proteins and their annotated locations for NP_001157724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.8, also known as variant 6) differs in the 5' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.8cy) has an alternate N-terminus compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52841.1
    UniProtKB/TrEMBL
    G5E8R1
    Related
    ENSMUSP00000109325.2, ENSMUST00000113695.8
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  6. NM_001164253.1NP_001157725.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

    See identical proteins and their annotated locations for NP_001157725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.9, also known as variant 7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.9cy) has an alternate N-terminus, has a short internal region of sequence differences and is shorter, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52843.1
    UniProtKB/TrEMBL
    G5E8R2
    Related
    ENSMUSP00000109326.2, ENSMUST00000113696.8
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  7. NM_001164254.1NP_001157726.1  tropomyosin alpha-1 chain isoform Tpm1.13

    See identical proteins and their annotated locations for NP_001157726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.13, also known as variant 8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The encoded isoform (Tpm1.13) has alternate N- and C- termini and is shorter, compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  8. NM_001164255.1NP_001157727.1  tropomyosin alpha-1 chain isoform Tpm1.10br

    See identical proteins and their annotated locations for NP_001157727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.10, also known as variant 9) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52844.1
    UniProtKB/TrEMBL
    E9Q452
    Related
    ENSMUSP00000109323.2, ENSMUST00000113693.8
    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin
  9. NM_001164256.1NP_001157728.1  tropomyosin alpha-1 chain isoform Tpm1.12br

    See identical proteins and their annotated locations for NP_001157728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.12, also known as variant 10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The resulting isoform (Tpm1.12br) has shorter and distinct N- and C-termini compared to isoform Tpm1.6cy.
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS52842.1
    UniProtKB/TrEMBL
    G5E8R0
    Related
    ENSMUSP00000109320.2, ENSMUST00000113690.8
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin
  10. NM_024427.4NP_077745.2  tropomyosin alpha-1 chain isoform Tpm1.6cy

    See identical proteins and their annotated locations for NP_077745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tpm1.6, also known as variant 3) represents one of the longest transcripts and encodes one of the longest isoforms (Tpm1.6cy).
    Source sequence(s)
    AC166370
    Consensus CDS
    CCDS23311.1
    UniProtKB/Swiss-Prot
    P58771
    UniProtKB/TrEMBL
    Q564G1
    Related
    ENSMUSP00000109337.3, ENSMUST00000113707.9
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66929872..66956954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154840.1XP_036010733.1  tropomyosin alpha-1 chain isoform X7

    Conserved Domains (1) summary
    pfam00261
    Location:48280
    Tropomyosin
  2. XM_006511044.2XP_006511107.1  tropomyosin alpha-1 chain isoform X6

    See identical proteins and their annotated locations for XP_006511107.1

    UniProtKB/TrEMBL
    E9Q448
    Related
    ENSMUSP00000109331.2, ENSMUST00000113701.8
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  3. XM_030244241.1XP_030100101.1  tropomyosin alpha-1 chain isoform X13

    Related
    ENSMUSP00000034928.5, ENSMUST00000034928.12
    Conserved Domains (2) summary
    PRK12472
    Location:18127
    PRK12472; hypothetical protein; Provisional
    pfam00261
    Location:90324
    Tropomyosin
  4. XM_006511051.5XP_006511114.1  tropomyosin alpha-1 chain isoform X12

    See identical proteins and their annotated locations for XP_006511114.1

    UniProtKB/TrEMBL
    E9Q453
    Related
    ENSMUSP00000109319.2, ENSMUST00000113689.8
    Conserved Domains (1) summary
    pfam00261
    Location:12244
    Tropomyosin
  5. XM_006511040.4XP_006511103.1  tropomyosin alpha-1 chain isoform X1

    UniProtKB/TrEMBL
    E9Q454
    Related
    ENSMUSP00000109317.2, ENSMUST00000113687.8
    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  6. XM_011242715.3XP_011241017.1  tropomyosin alpha-1 chain isoform X3

    Conserved Domains (2) summary
    pfam00261
    Location:48259
    Tropomyosin
    pfam16526
    Location:1372
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  7. XM_006511039.4XP_006511102.1  tropomyosin alpha-1 chain isoform X2

    Conserved Domains (1) summary
    pfam00261
    Location:48259
    Tropomyosin
  8. XM_006511042.4XP_006511105.1  tropomyosin alpha-1 chain isoform X4

    See identical proteins and their annotated locations for XP_006511105.1

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  9. XM_006511049.5XP_006511112.1  tropomyosin alpha-1 chain isoform X8

    UniProtKB/TrEMBL
    E9Q455
    Related
    ENSMUSP00000109316.2, ENSMUST00000113686.8
    Conserved Domains (1) summary
    pfam00261
    Location:12223
    Tropomyosin
  10. XM_011242716.4XP_011241018.1  tropomyosin alpha-1 chain isoform X9

    See identical proteins and their annotated locations for XP_011241018.1

    Conserved Domains (1) summary
    pfam00261
    Location:12223
    Tropomyosin
  11. XM_030244240.2XP_030100100.1  tropomyosin alpha-1 chain isoform X10

    Related
    ENSMUSP00000109314.2, ENSMUST00000113684.8
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  12. XM_006511041.2XP_006511104.1  tropomyosin alpha-1 chain isoform X5

    See identical proteins and their annotated locations for XP_006511104.1

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  13. XM_006511050.4XP_006511113.1  tropomyosin alpha-1 chain isoform X11

    See identical proteins and their annotated locations for XP_006511113.1

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
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