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Traf1 TNF receptor-associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 22029, updated on 11-Jul-2021

Summary

Official Symbol
Traf1provided by MGI
Official Full Name
TNF receptor-associated factor 1provided by MGI
Primary source
MGI:MGI:101836
See related
Ensembl:ENSMUSG00000026875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732496E14Rik
Expression
Biased expression in spleen adult (RPKM 9.8), thymus adult (RPKM 8.2) and 13 other tissues See more
Orthologs
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Genomic context

See Traf1 in Genome Data Viewer
Location:
2; 2 B
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34831762..34851784, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34941750..34961812, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34798778..34817292, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 19 Neighboring gene predicted gene, 24905 Neighboring gene predicted gene, 52552 Neighboring gene predicted gene, 46733 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TNF receptor-associated factor 1
NP_001313530.1
NP_033447.2
XP_011237352.1
XP_011237353.1
XP_011237354.1
XP_011237355.1
XP_011237356.1
XP_036016379.1
XP_036016380.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326601.1NP_001313530.1  TNF receptor-associated factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029135, AL929068, BY209774
    Consensus CDS
    CCDS15956.1
    UniProtKB/Swiss-Prot
    P39428
    Related
    ENSMUSP00000130759.2, ENSMUST00000172159.8
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  2. NM_009421.4NP_033447.2  TNF receptor-associated factor 1

    See identical proteins and their annotated locations for NP_033447.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029135, AL929068
    Consensus CDS
    CCDS15956.1
    UniProtKB/Swiss-Prot
    P39428
    Related
    ENSMUSP00000108687.2, ENSMUST00000113064.8
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34831762..34851784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239053.4XP_011237355.1  TNF receptor-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011237355.1

    UniProtKB/Swiss-Prot
    P39428
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  2. XM_011239052.4XP_011237354.1  TNF receptor-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011237354.1

    UniProtKB/Swiss-Prot
    P39428
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  3. XM_011239050.4XP_011237352.1  TNF receptor-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011237352.1

    UniProtKB/Swiss-Prot
    P39428
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  4. XM_011239051.4XP_011237353.1  TNF receptor-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011237353.1

    UniProtKB/Swiss-Prot
    P39428
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  5. XM_011239054.4XP_011237356.1  TNF receptor-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011237356.1

    UniProtKB/Swiss-Prot
    P39428
    Related
    ENSMUSP00000028234.6, ENSMUST00000028234.12
    Conserved Domains (3) summary
    cd03779
    Location:260406
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    TIGR02168
    Location:126257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  6. XM_036160486.1XP_036016379.1  TNF receptor-associated factor 1 isoform X2

    Conserved Domains (2) summary
    cl02446
    Location:260287
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    pfam16673
    Location:180237
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  7. XM_036160487.1XP_036016380.1  TNF receptor-associated factor 1 isoform X3

    Conserved Domains (1) summary
    pfam16673
    Location:180228
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
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