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HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 [ Homo sapiens (human) ]

Gene ID: 220988, updated on 7-Apr-2024

Summary

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Official Symbol
HNRNPA3provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A3provided by HGNC
Primary source
HGNC:HGNC:24941
See related
Ensembl:ENSG00000170144 MIM:605372; AllianceGenome:HGNC:24941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBRNP; HNRPA3; D10S102; 2610510D13Rik
Summary
Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 56.8), lymph node (RPKM 56.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (177212794..177223959)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177695036..177706189)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178077522..178088687)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:178062767-178063304 Neighboring gene keratin 8 pseudogene 40 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:178068917-178069879 Neighboring gene uncharacterized LOC105373759 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:178077489-178078160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12143 Neighboring gene microRNA 4444-1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 5 Neighboring gene NFE2 like bZIP transcription factor 2 Neighboring gene microRNA 3128

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis. Fifita JA, et al. Neurodegener Dis, 2017. PMID 29131108
  2. Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene. Davidson YS, et al. Acta Neuropathol Commun, 2017 Apr 21. PMID 28431575, Free PMC Article
  3. Telomeric DNA-binding activities of heterogeneous nuclear ribonucleoprotein A3 in vitro and in vivo. Huang PR, et al. Biochim Biophys Acta, 2010 Oct. PMID 20600361
  4. Heterogeneous nuclear ribonucleoprotein A3 binds single-stranded telomeric DNA and inhibits telomerase extension in vitro. Huang PR, et al. Biochim Biophys Acta, 2008 Feb. PMID 17919748
  5. Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells. Mishra N, et al. J Cell Biochem, 2018 Aug. PMID 29693745

See all (236) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.
    Title: Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.
  2. Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
    Title: Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
  3. results indicated a specific interaction of A3B with hnRNP A3 (heterogeneous nuclear ribonucleoprotein). This interaction was verified by co-immunoprecipitation and was found to be RNA-dependent. Furthermore, A3B and hnRNP A3 colocalized as evident from immunofluorescence analysis.
    Title: Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.
  4. This study showed that HNRNPA3 variants identified in Australian patients with familial amyotrophic lateral sclerosis (FALS) and associated alternate allele frequencies in cases and controls.
    Title: Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.
  5. Study investigated the pattern of hnRNP A1, A2/B1 and A3 immunostaining across a range of clinical, pathological and genetic forms of Frontotemporal Lobar Degeneration and Motor Neurone Disease. Data suggest there might be a derangement of movement of hnRNP A1, and other hnRNP proteins, across all pathological forms of Frontotemporal Lobar Degeneration beyond that involving just TDP-43 or FUS.
    Title: Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
  6. Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition.
    Title: Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
  7. The results of this study suggested that mutations in hnRNPA1, A2/B1, and A3 genes are a rare finding in amyotrophic lateral sclerosis.
    Title: Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis.
  8. characterization of hnRNP A3 in human and mouse cell lines
    Title: Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.
  9. Results suggest that hnRNP A3 is associated with telomere in vivo and acts as a negative regulator of telomere length maintenance.
    Title: Telomeric DNA-binding activities of heterogeneous nuclear ribonucleoprotein A3 in vitro and in vivo.
  10. These biochemical properties of hnRNP A3 suggest that hnRNP A3 can participate in telomere regulation in vivo.
    Title: Heterogeneous nuclear ribonucleoprotein A3 binds single-stranded telomeric DNA and inhibits telomerase extension in vitro.
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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with HNRNPA3 is increased by RRE PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138232, MGC142030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A3
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330247.2 → NP_001317176.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS82536.1
    UniProtKB/TrEMBL
    A0A7I2V4G0, B4DDB6, D3DPF5
    Related
    ENSP00000408487.1, ENST00000411529.6
    Conserved Domains (3) summary
    pfam11627
    Location:309 → 325
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  2. NM_001330248.2 → NP_001317177.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS82536.1
    UniProtKB/TrEMBL
    A0A7I2V4G0, B4DDB6, D3DPF5
    Related
    ENSP00000503186.1, ENST00000676874.1
    Conserved Domains (3) summary
    pfam11627
    Location:309 → 325
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  3. NM_001330249.2 → NP_001317178.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS2273.1
    UniProtKB/Swiss-Prot
    D3DPF4, P51991, Q53RW7, Q6URK5
    UniProtKB/TrEMBL
    A0A384NL63, A0A7I2V402
    Related
    ENSP00000504135.1, ENST00000678111.1
    Conserved Domains (3) summary
    pfam11627
    Location:331 → 347
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  4. NM_001330250.2 → NP_001317179.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS92902.1
    UniProtKB/TrEMBL
    A0A7I2V2R3, A0A7I2V5D8
    Related
    ENSP00000504649.1, ENST00000677043.1
    Conserved Domains (3) summary
    pfam11627
    Location:285 → 300
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  5. NM_001330251.2 → NP_001317180.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS92902.1
    UniProtKB/TrEMBL
    A0A7I2V2R3, A0A7I2V5D8
    Related
    ENSP00000503339.1, ENST00000676681.1
    Conserved Domains (3) summary
    pfam11627
    Location:285 → 300
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  6. NM_001395170.1 → NP_001382099.1  heterogeneous nuclear ribonucleoprotein A3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC079305
    UniProtKB/TrEMBL
    B4E3E6
    Conserved Domains (2) summary
    smart00360
    Location:14 → 84
    RRM; RNA recognition motif
    cl17169
    Location:105 → 179
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_194247.4 → NP_919223.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_919223.1

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS2273.1
    UniProtKB/Swiss-Prot
    D3DPF4, P51991, Q53RW7, Q6URK5
    UniProtKB/TrEMBL
    A0A384NL63, A0A7I2V402
    Related
    ENSP00000376309.2, ENST00000392524.7
    Conserved Domains (3) summary
    pfam11627
    Location:331 → 347
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RNA

  1. NR_138470.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Related
    ENST00000483137.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    177212794..177223959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177695036..177706189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51991.2 GenPept UniProtKB/Swiss-Prot:P51991

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