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ARL5B ADP ribosylation factor like GTPase 5B [ Homo sapiens (human) ]

Gene ID: 221079, updated on 5-Mar-2024

Summary

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Official Symbol
ARL5Bprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 5Bprovided by HGNC
Primary source
HGNC:HGNC:23052
See related
Ensembl:ENSG00000165997 MIM:608909; AllianceGenome:HGNC:23052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL8
Summary
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

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See ARL5B in Genome Data Viewer
Location:
10p12.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (18659431..18681639)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (18678534..18700749)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18948360..18970568)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC124902386 Neighboring gene uncharacterized LOC124902387 Neighboring gene NANOG hESC enhancer GRCh37_chr10:18841481-18841982 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2184 Neighboring gene uncharacterized LOC105376440 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:19041189-19042388 Neighboring gene AIFM1 pseudogene 1 Neighboring gene MPRA-validated peak892 silencer Neighboring gene uncharacterized LOC107984180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down. Houghton FJ, et al. FEBS Lett, 2022 Sep. PMID 35789482
  2. Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling. Zhang L, et al. Curr Cancer Drug Targets, 2022. PMID 35546774
  3. Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation. Xie X, et al. Eur J Immunol, 2020 Aug. PMID 32250445
  4. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. Houghton FJ, et al. Exp Cell Res, 2012 Mar 10. PMID 22245584
  5. Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B. Jaimon E, et al. J Biol Chem, 2021 Dec. PMID 34798070, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.
    Title: Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.
  2. Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.
    Title: Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.
  3. Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.
    Title: Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.
  4. miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.
    Title: miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.
  5. Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.
    Title: Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.
  6. Depletion of either Arl5b or AP4 results in the accumulation of APP.
    Title: Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.
  7. Arl5b is a trans-golgi-network-localised small G protein that plays a key role in regulating transport along the endosome-trans-golgi network pathway
    Title: Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.
  8. Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
    Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ARL5B, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 5B
Names
ADP-ribosylation factor-like 5B
ADP-ribosylation factor-like 8
ADP-ribosylation factor-like protein 8
ADP-ribosylation-like factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178815.5 → NP_848930.1  ADP-ribosylation factor-like protein 5B

    See identical proteins and their annotated locations for NP_848930.1

    Status: VALIDATED

    Source sequence(s)
    AL133611, AL512641
    Consensus CDS
    CCDS7131.1
    UniProtKB/Swiss-Prot
    Q96KC2
    UniProtKB/TrEMBL
    B0YIW9
    Related
    ENSP00000366487.3, ENST00000377275.4
    Conserved Domains (1) summary
    cd04153
    Location:3 → 175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    18659431..18681639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252400.2 → XP_005252457.1  ADP-ribosylation factor-like protein 5B isoform X1

    See identical proteins and their annotated locations for XP_005252457.1

    Conserved Domains (2) summary
    smart00178
    Location:8 → 148
    SAR; Sar1p-like members of the Ras-family of small GTPases
    cl21455
    Location:3 → 147
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_005252401.5 → XP_005252458.1  ADP-ribosylation factor-like protein 5B isoform X2

    See identical proteins and their annotated locations for XP_005252458.1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    18678534..18700749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365129.1 → XP_054221104.1  ADP-ribosylation factor-like protein 5B isoform X1

  2. XM_054365130.1 → XP_054221105.1  ADP-ribosylation factor-like protein 5B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KC2.1 GenPept UniProtKB/Swiss-Prot:Q96KC2

Gene LinkOut

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