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ADGRG5 adhesion G protein-coupled receptor G5 [ Homo sapiens (human) ]

Gene ID: 221188, updated on 11-Apr-2024

Summary

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Official Symbol
ADGRG5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G5provided by HGNC
Primary source
HGNC:HGNC:19010
See related
Ensembl:ENSG00000159618 MIM:616965; AllianceGenome:HGNC:19010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR27; GPR114
Summary
This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57529073..57577189)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63324271..63372382)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57576555..57611101)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene coenzyme Q9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57506902-57507423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57507424-57507944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57508610-57509398 Neighboring gene RNA polymerase II subunit C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57519658-57520454 Neighboring gene docking protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57541954-57542946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57543642-57544142 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43689 Neighboring gene coiled-coil domain containing 102A Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57562855-57563355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57566372-57566931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57566932-57567490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10900 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57598339-57598840 Neighboring gene uncharacterized LOC105371291 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10902 Neighboring gene uncharacterized LOC107984889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10903 Neighboring gene high mobility group box 3 pseudogene 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. Wilde C, et al. FASEB J, 2016 Feb. PMID 26499266
  2. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. Engelman CD, et al. J Steroid Biochem Mol Biol, 2010 Oct. PMID 20600896, Free PMC Article
  3. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
  4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G5
Names
G protein-coupled receptor 114
G protein-coupled receptor PGR27
probable G-protein coupled receptor 114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304376.3 → NP_001291305.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001291305.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK292783, AY358447, BC032401, BM193863
    Consensus CDS
    CCDS10785.1
    UniProtKB/Swiss-Prot
    A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
    Related
    ENSP00000290823.4, ENST00000349457.8
    Conserved Domains (2) summary
    pfam01825
    Location:187 → 232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245 → 518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

  2. NM_001318481.2 → NP_001305410.1  adhesion G-protein coupled receptor G5 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK292783, AK303661, AY140956, BC032401, BM193863
    UniProtKB/TrEMBL
    B4E148
    Conserved Domains (2) summary
    pfam01825
    Location:187 → 232
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:247 → 363
    7tm_4; Olfactory receptor

  3. NM_153837.4 → NP_722579.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_722579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC004382, AK292783, AK303661, AY358447, BC032401, BM193863
    Consensus CDS
    CCDS10785.1
    UniProtKB/Swiss-Prot
    A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
    Related
    ENSP00000342981.4, ENST00000340339.4
    Conserved Domains (2) summary
    pfam01825
    Location:187 → 232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245 → 518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57529073..57577189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433776.1 → XP_047289732.1  adhesion G-protein coupled receptor G5 isoform X2

  2. XM_011522949.3 → XP_011521251.2  adhesion G-protein coupled receptor G5 isoform X1

  3. XM_047433778.1 → XP_047289734.1  adhesion G-protein coupled receptor G5 isoform X5

  4. XM_047433777.1 → XP_047289733.1  adhesion G-protein coupled receptor G5 isoform X3

  5. XM_011522950.3 → XP_011521252.1  adhesion G-protein coupled receptor G5 isoform X4

    See identical proteins and their annotated locations for XP_011521252.1

    UniProtKB/Swiss-Prot
    A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
    Conserved Domains (2) summary
    pfam01825
    Location:187 → 232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245 → 518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63324271..63372382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379814.1 → XP_054235789.1  adhesion G-protein coupled receptor G5 isoform X2

  2. XM_054379813.1 → XP_054235788.1  adhesion G-protein coupled receptor G5 isoform X1

  3. XM_054379817.1 → XP_054235792.1  adhesion G-protein coupled receptor G5 isoform X5

  4. XM_054379815.1 → XP_054235790.1  adhesion G-protein coupled receptor G5 isoform X3

  5. XM_054379816.1 → XP_054235791.1  adhesion G-protein coupled receptor G5 isoform X4

    UniProtKB/Swiss-Prot
    A0A024R6S3, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14, Q8IZF4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZF4.3 GenPept UniProtKB/Swiss-Prot:Q8IZF4

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