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Ttf1 transcription termination factor, RNA polymerase I [ Mus musculus (house mouse) ]

Gene ID: 22130, updated on 23-Jun-2021

Summary

Official Symbol
Ttf1provided by MGI
Official Full Name
transcription termination factor, RNA polymerase Iprovided by MGI
Primary source
MGI:MGI:105044
See related
Ensembl:ENSMUSG00000026803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TTF-1; TTF-I; AV245725
Annotation information
Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), bladder adult (RPKM 3.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ttf1 in Genome Data Viewer
Location:
2; 2 A3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28950211..28977668)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29060199..29087656)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (28915783..28943170)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cilia and flagella associated protein 77 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene senataxin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription termination factor 1
Names
RNA polymerase I termination factor
transcription termination factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009442.2NP_033468.2  transcription termination factor 1

    See identical proteins and their annotated locations for NP_033468.2

    Status: VALIDATED

    Source sequence(s)
    AK163606, BC059011, BE332152, BU757299
    Consensus CDS
    CCDS38089.1
    UniProtKB/Swiss-Prot
    Q62187
    UniProtKB/TrEMBL
    Q3TQG6
    Related
    ENSMUSP00000097809.4, ENSMUST00000100237.4
    Conserved Domains (1) summary
    pfam13921
    Location:595650
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28950211..28977668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160512.1XP_036016405.1  transcription termination factor 1 isoform X1

    Conserved Domains (1) summary
    pfam13921
    Location:625680
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  2. XM_006497852.2XP_006497915.1  transcription termination factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006497915.1

    UniProtKB/Swiss-Prot
    Q62187
    Conserved Domains (1) summary
    pfam13921
    Location:595650
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RNA

  1. XR_374069.2 RNA Sequence

  2. XR_004939514.1 RNA Sequence

  3. XR_004939513.1 RNA Sequence

  4. XR_374068.2 RNA Sequence

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