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Ttr transthyretin [ Mus musculus (house mouse) ]

Gene ID: 22139, updated on 21-Apr-2024

Summary

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Official Symbol
Ttrprovided by MGI
Official Full Name
transthyretinprovided by MGI
Primary source
MGI:MGI:98865
See related
Ensembl:ENSMUSG00000061808 AllianceGenome:MGI:98865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
prealbumin
Summary
This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]
Expression
Biased expression in liver adult (RPKM 3655.3), liver E18 (RPKM 2930.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A2; 18 11.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20797266..20807383)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20664209..20674326)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46630 Neighboring gene desmoglein 2 Neighboring gene STARR-seq mESC enhancer starr_43967 Neighboring gene predicted gene 16090 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 Neighboring gene predicted gene, 31437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance. Wu B, et al. J Mol Endocrinol, 2023 Jul 1. PMID 37314245
  2. Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models. Saito-Takatsuji H, et al. Int J Mol Sci, 2023 Feb 13. PMID 36835151, Free PMC Article
  3. Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function. Rawat RS, et al. Elife, 2022 Oct 13. PMID 36226913, Free PMC Article
  4. TTR exon-humanized mouse optimal for verifying new therapies for FAP. Li Z, et al. Biochem Biophys Res Commun, 2022 Apr 9. PMID 35176627
  5. Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation. Eira J, et al. Front Cell Dev Biol, 2021. PMID 34820375, Free PMC Article

See all (263) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway.
    Title: Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway.
  2. Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance.
    Title: Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance.
  3. Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
    Title: Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
  4. Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.
    Title: Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.
  5. Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.
    Title: Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.
  6. Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
    Title: Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
  7. Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.
    Title: Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.
  8. in the diabetic retinopathy environment, TTR might affect the lncRNA MEG3/miR-223-3p axis by the direct binding with PABPC1, and finally repress retinal vessel proliferation.
    Title: Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.
  9. TTR is not synthesized in brain resident cells in the ischemic infarct core and adjacent peri-infarct area.
    Title: Transthyretin expression in the postischemic brain.
  10. Knockdown of Ttr in cultured cerebellar granule neurons significantly decreased the delta receptor expression; whereas overexpressing Ttr in cortical neurons increased the delta receptor expression. In vivo analysis of Ttr-/- mice revealed a significant decrease of the surface expression of the delta-GABAA-Rs in cerebellar granule neurons. Together, studies identified Ttr as a novel regulator of the delta-GABAA-Rs.
    Title: Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107649

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables thyroid hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transthyretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013697.5 → NP_038725.1  transthyretin precursor

    See identical proteins and their annotated locations for NP_038725.1

    Status: REVIEWED

    Source sequence(s)
    AC129078, CD742426
    Consensus CDS
    CCDS29085.1
    UniProtKB/Swiss-Prot
    P07309
    UniProtKB/TrEMBL
    Q5M9K1, Q9D6A4
    Related
    ENSMUSP00000074783.4, ENSMUST00000075312.5
    Conserved Domains (1) summary
    smart00095
    Location:27 → 147
    TR_THY; Transthyretin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    20797266..20807383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250412.1 → XP_030106272.1  transthyretin isoform X1

    UniProtKB/Swiss-Prot
    P07309
    UniProtKB/TrEMBL
    Q5M9K1, Q9D6A4
    Conserved Domains (1) summary
    smart00095
    Location:27 → 147
    TR_THY; Transthyretin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07309.1 GenPept UniProtKB/Swiss-Prot:P07309

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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