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FCGRT Fc gamma receptor and transporter [ Homo sapiens (human) ]

Gene ID: 2217, updated on 3-Apr-2024

Summary

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Official Symbol
FCGRTprovided by HGNC
Official Full Name
Fc gamma receptor and transporterprovided by HGNC
Primary source
HGNC:HGNC:3621
See related
Ensembl:ENSG00000104870 MIM:601437; AllianceGenome:HGNC:3621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRN; FcgammaRn; alpha-chain
Summary
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FCGRT in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49512661..49526428)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52512666..52526423)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50015918..50029685)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003846-50004617 Neighboring gene Sharpr-MPRA regulatory region 15417 Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50014938-50015500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50017428-50018141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene nitric oxide synthase interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The therapeutic age of the neonatal Fc receptor. Pyzik M, et al. Nat Rev Immunol, 2023 Jul. PMID 36726033, Free PMC Article
  2. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18. Chen X, et al. mBio, 2022 Aug 30. PMID 35862785, Free PMC Article
  3. Human IgE does not bind to human FcRn. Brinkhaus M, et al. Sci Rep, 2022 Jan 7. PMID 34996950, Free PMC Article
  4. Research progress on neonatal Fc receptor and its application. Hu M, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2021 Aug 25. PMID 34704415, Free PMC Article
  5. Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus. Yanis R, et al. Lupus, 2021 Oct. PMID 34634960

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
    Title: Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
  2. The therapeutic age of the neonatal Fc receptor.
    Title: The therapeutic age of the neonatal Fc receptor.
  3. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
    Title: Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
  4. Human IgE does not bind to human FcRn.
    Title: Human IgE does not bind to human FcRn.
  5. An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
    Title: An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
  6. Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
    Title: Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
  7. Research progress on neonatal Fc receptor and its application.
    Title: Research progress on neonatal Fc receptor and its application.
  8. Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
    Title: Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
  9. Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy.
    Title: Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy.
  10. V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor.
    Title: V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor.
Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment of IgG receptor and transporter
Fc fragment of IgG, receptor, transporter, alpha
FcRn alpha chain
IgG Fc fragment receptor transporter alpha chain
heavy chain of the major histocompatibility complex class I-like Fc receptor
immunoglobulin receptor, intestinal, heavy chain
major histocompatibility complex class I-like Fc receptor
neonatal Fc receptor
neonatal Fc-receptor for Ig
transmembrane alpha chain of the neonatal receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136019.3 → NP_001129491.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC010619, BC091487, BE245284
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
    Related
    ENSP00000221466.4, ENST00000221466.10
    Conserved Domains (2) summary
    cd21011
    Location:198 → 290
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25 → 197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_001411064.1 → NP_001397993.1  IgG receptor FcRn large subunit p51 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1 and skips an internal exon. It encodes a shorter protein (2), compared to isoform 1.
    Source sequence(s)
    AC010619
    Consensus CDS
    CCDS92663.1
    UniProtKB/TrEMBL
    M0R0A9
    Related
    ENSP00000471118.1, ENST00000596975.5

  3. NM_004107.5 → NP_004098.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC008734, BE245284
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
    Related
    ENSP00000410798.2, ENST00000426395.7
    Conserved Domains (2) summary
    cd21011
    Location:198 → 290
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25 → 197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49512661..49526428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438411.1 → XP_047294367.1  IgG receptor FcRn large subunit p51 isoform X3

  2. XM_047438408.1 → XP_047294364.1  IgG receptor FcRn large subunit p51 isoform X1

  3. XM_047438410.1 → XP_047294366.1  IgG receptor FcRn large subunit p51 isoform X2

  4. XM_047438412.1 → XP_047294368.1  IgG receptor FcRn large subunit p51 isoform X4

    Related
    ENSP00000469933.1, ENST00000600273.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52512666..52526423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320202.1 → XP_054176177.1  IgG receptor FcRn large subunit p51 isoform X3

  2. XM_054320200.1 → XP_054176175.1  IgG receptor FcRn large subunit p51 isoform X1

  3. XM_054320201.1 → XP_054176176.1  IgG receptor FcRn large subunit p51 isoform X2

  4. XM_054320203.1 → XP_054176178.1  IgG receptor FcRn large subunit p51 isoform X4

  5. XM_054320199.1 → XP_054176174.1  IgG receptor FcRn large subunit p51 isoform X5

    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55899.1 GenPept UniProtKB/Swiss-Prot:P55899

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