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Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Mus musculus (house mouse) ]

Gene ID: 22195, updated on 2-May-2024

Summary

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Official Symbol
Ube2l3provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2L 3provided by MGI
Primary source
MGI:MGI:109240
See related
Ensembl:ENSMUSG00000038965 AllianceGenome:MGI:109240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UbcM4; Ubce7
Summary
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; heart; immune system; lung; and reproductive system. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 45.0), liver E14 (RPKM 37.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 10.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16969879..17019363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17152015..17201512, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene RIMS binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin. Peris-Moreno D, et al. Cells, 2021 Aug 3. PMID 34440743, Free PMC Article
  2. The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes. Eldridge MJG, et al. Cell Rep, 2017 Jan 31. PMID 28147281, Free PMC Article
  3. Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4. Moynihan TP, et al. Mamm Genome, 1999 Oct. PMID 10501966
  4. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Harbers K, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901595, Free PMC Article
  5. A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. Robinson PA, et al. Mamm Genome, 1995 Oct. PMID 8563171

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-1beta turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.
    Title: IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.
  2. UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
    Title: UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.
  3. UBE2L3 depletion increases pro-IL-1beta levels.
    Title: The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Transgenic (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 L3
Names
E2 ubiquitin-conjugating enzyme L3
ubiquitin carrier protein L3
ubiquitin-conjugating enzyme 7
ubiquitin-protein ligase L3
NP_001406151.1
NP_001406152.1
NP_001406153.1
NP_001406154.1
NP_001406155.1
NP_001406156.1
NP_001406158.1
NP_033482.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419222.1 → NP_001406151.1  ubiquitin-conjugating enzyme E2 L3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154667

  2. NM_001419223.1 → NP_001406152.1  ubiquitin-conjugating enzyme E2 L3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154667
    Related
    ENSMUSP00000156283.2, ENSMUST00000232668.2

  3. NM_001419224.1 → NP_001406153.1  ubiquitin-conjugating enzyme E2 L3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154667

  4. NM_001419225.1 → NP_001406154.1  ubiquitin-conjugating enzyme E2 L3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154667

  5. NM_001419226.1 → NP_001406155.1  ubiquitin-conjugating enzyme E2 L3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154667
    UniProtKB/TrEMBL
    A0A338P7E5
    Related
    ENSMUSP00000156336.2, ENSMUST00000231643.2

  6. NM_001419227.1 → NP_001406156.1  ubiquitin-conjugating enzyme E2 L3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154667

  7. NM_001419229.1 → NP_001406158.1  ubiquitin-conjugating enzyme E2 L3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154667
    Related
    ENSMUSP00000156034.2, ENSMUST00000232035.2

  8. NM_009456.3 → NP_033482.1  ubiquitin-conjugating enzyme E2 L3 isoform 1

    See identical proteins and their annotated locations for NP_033482.1

    Status: VALIDATED

    Source sequence(s)
    AC154667
    Consensus CDS
    CCDS27997.1
    UniProtKB/Swiss-Prot
    P68037
    UniProtKB/TrEMBL
    Q3TIH9, Q561N4
    Related
    ENSMUSP00000087658.6, ENSMUST00000090192.12
    Conserved Domains (1) summary
    smart00212
    Location:6 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RNA

  1. NR_185043.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

  2. NR_185044.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

  3. NR_185045.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

  4. NR_185046.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

  5. NR_185047.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154667

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16969879..17019363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68037.1 GenPept UniProtKB/Swiss-Prot:P68037

Gene LinkOut

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