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Uba1y ubiquitin-activating enzyme, Chr Y [ Mus musculus (house mouse) ]

Gene ID: 22202, updated on 8-Feb-2024

Summary

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Official Symbol
Uba1yprovided by MGI
Official Full Name
ubiquitin-activating enzyme, Chr Yprovided by MGI
Primary source
MGI:MGI:98891
See related
Ensembl:ENSMUSG00000069053 AllianceGenome:MGI:98891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sby; Ube-2; Ube1y; Ube1ay; Ube1y1; A1s9Y-1; Ube1y-1
Summary
Enables ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adrenal gland; brain; liver; and testis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 6.5) See more
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Genomic context

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See Uba1y in Genome Data Viewer
Location:
Y; Ypter
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (818612..843684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (818612..843684)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48292 Neighboring gene STARR-seq mESC enhancer starr_48293 Neighboring gene zinc finger protein 1, Y-linked Neighboring gene ras homolog A translocated to the Y, pseudogene 3 Neighboring gene lysine demethylase 5D Neighboring gene STARR-seq mESC enhancer starr_48294

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Ciechanover A, et al. Cell, 1984 May. PMID 6327060
  2. Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Finley D, et al. Cell, 1984 May. PMID 6327059
  3. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Mitchell MJ, et al. Nature, 1992 Oct 8. PMID 1406968
  4. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Lévy N, et al. Mamm Genome, 2000 Feb. PMID 10656933
  5. The ubiquitin-proteasome pathway: on protein death and cell life. Ciechanover A. EMBO J, 1998 Dec 15. PMID 9857172, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin activating enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-like modifier-activating enzyme 1 Y
Names
ubiquitin-activating enzyme E1 Y
ubiquitin-activating enzyme E1, Chr Y 1
NP_001343972.1
XP_030107423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357043.1 → NP_001343972.1  ubiquitin-like modifier-activating enzyme 1 Y

    Status: VALIDATED

    Source sequence(s)
    AC139318, AF150963
    Consensus CDS
    CCDS30540.1
    UniProtKB/Swiss-Prot
    P31254, Q60639, Q8CDH7, Q9QYS4, Q9QZX2
    Related
    ENSMUSP00000140543.2, ENSMUST00000190013.7
    Conserved Domains (1) summary
    TIGR01408
    Location:48 → 1055
    Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    818612..843684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251563.1 → XP_030107423.1  ubiquitin-like modifier-activating enzyme 1 Y isoform X1

    Conserved Domains (1) summary
    TIGR01408
    Location:48 → 1084
    Ube1; ubiquitin-activating enzyme E1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011667.2: Suppressed sequence

    Description
    NM_011667.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31254.2 GenPept UniProtKB/Swiss-Prot:P31254

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