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Dpysl3 dihydropyrimidinase-like 3 [ Mus musculus (house mouse) ]

Gene ID: 22240, updated on 23-Jun-2021

Summary

Official Symbol
Dpysl3provided by MGI
Official Full Name
dihydropyrimidinase-like 3provided by MGI
Primary source
MGI:MGI:1349762
See related
Ensembl:ENSMUSG00000024501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U; Ul; CRMP; TUC4; Ulip; DRP-3; Ulip1; CRMP-4; ULIP-1
Summary
This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Biased expression in CNS E18 (RPKM 272.7), whole brain E14.5 (RPKM 195.1) and 7 other tissues See more
Orthologs
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Genomic context

See Dpysl3 in Genome Data Viewer
Location:
18; 18 B3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (43454044..43571351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (43320979..43438286, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (43483881..43552985, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8181 Neighboring gene serine/threonine kinase 32A Neighboring gene predicted gene, 31647 Neighboring gene predicted gene, 41714 Neighboring gene predicted gene 3650 Neighboring gene eukaryotic translation initiation factor 3, subunit J2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables filamin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 3
Names
collapsin response mediator protein 4
unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136086.2NP_001129558.1  dihydropyrimidinase-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001129558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b.
    Source sequence(s)
    AC101718, AK133040, BQ175584
    Consensus CDS
    CCDS50269.1
    UniProtKB/TrEMBL
    Q3TT92
    Related
    ENSMUSP00000113711.2, ENSMUST00000118043.8
    Conserved Domains (2) summary
    PRK09060
    Location:15465
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:15469
    D-hydantoinase; D-hydantoinase
  2. NM_001291455.1NP_001278384.1  dihydropyrimidinase-related protein 3 CRMP4b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3).
    Source sequence(s)
    AC101718, AK149024, BQ175584
    Consensus CDS
    CCDS79639.1
    UniProtKB/TrEMBL
    E9PWE8
    Related
    ENSMUSP00000112928.2, ENSMUST00000121805.9
    Conserved Domains (2) summary
    PRK09060
    Location:130580
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:130584
    D-hydantoinase; D-hydantoinase
  3. NM_009468.5NP_033494.1  dihydropyrimidinase-related protein 3 CRMP4a

    See identical proteins and their annotated locations for NP_033494.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b.
    Source sequence(s)
    AC101718, BQ175584
    Consensus CDS
    CCDS37801.1
    UniProtKB/Swiss-Prot
    Q62188
    Related
    ENSMUSP00000025379.8, ENSMUST00000025379.14
    Conserved Domains (2) summary
    PRK09060
    Location:17467
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:17471
    D-hydantoinase; D-hydantoinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    43454044..43571351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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