Format

Send to:

Choose Destination

Umod uromodulin [ Mus musculus (house mouse) ]

Gene ID: 22242, updated on 21-Oct-2021

Summary

Official Symbol
Umodprovided by MGI
Official Full Name
uromodulinprovided by MGI
Primary source
MGI:MGI:102674
See related
Ensembl:ENSMUSG00000030963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
THP; Urehd1; urehr4
Summary
This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward kidney adult (RPKM 1277.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Umod in Genome Data Viewer
Location:
7 F2; 7 63.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119061931..119078485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119462708..119479262, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (126606380..126622769, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53364 Neighboring gene glycoprotein 2 (zymogen granule membrane) Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC14034

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular chloride ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within citric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within connective tissue replacement IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within creatinine homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within juxtaglomerular apparatus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within loop of Henle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric ascending thin limb development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within metanephric distal convoluted tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within metanephric thick ascending limb development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within micturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organ or tissue specific immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to vacuole IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport into plasma membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renal sodium ion absorption IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renal sodium ion absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urate salt excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in anchored component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
uromodulin
Names
Tamm-Horsfall urinary glycoprotein
uromucoid

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278605.1NP_001265534.1  uromodulin preproprotein

    See identical proteins and their annotated locations for NP_001265534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125147, AK165507, BB843740
    Consensus CDS
    CCDS21780.1
    UniProtKB/Swiss-Prot
    Q91X17
    Related
    ENSMUSP00000146652.2, ENSMUST00000209095.2
    Conserved Domains (5) summary
    smart00179
    Location:6598
    EGF_CA; Calcium-binding EGF-like domain
    smart00241
    Location:335584
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:464584
    Zona_pellucida; Zona pellucida-like domain
    pfam12662
    Location:88110
    cEGF; Complement Clr-like EGF-like
    pfam12947
    Location:111147
    EGF_3; EGF domain
  2. NM_009470.5NP_033496.1  uromodulin preproprotein

    See identical proteins and their annotated locations for NP_033496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125147, AK085460, AK164688
    Consensus CDS
    CCDS21780.1
    UniProtKB/Swiss-Prot
    Q91X17
    Related
    ENSMUSP00000033263.5, ENSMUST00000033263.6
    Conserved Domains (5) summary
    smart00179
    Location:6598
    EGF_CA; Calcium-binding EGF-like domain
    smart00241
    Location:335584
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:464584
    Zona_pellucida; Zona pellucida-like domain
    pfam12662
    Location:88110
    cEGF; Complement Clr-like EGF-like
    pfam12947
    Location:111147
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119061931..119078485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center