Uck1 uridine-cytidine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uck1provided by MGI
Official Full Name: uridine-cytidine kinase 1provided by MGI
Primary source: MGI:MGI:98904
See related: Ensembl:ENSMUSG00000002550 AllianceGenome:MGI:98904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: URK1; Umpk
Summary: Enables uridine kinase activity. Involved in UMP salvage. Predicted to be active in cytosol. Is expressed in nervous system; respiratory system; and urinary system. Orthologous to human UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in mammary gland adult (RPKM 75.9), adrenal adult (RPKM 70.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32145014..32150117, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32255002..32260105, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI505244 (e-PCR)
- UniSTS:164154

Umpk (e-PCR), detects polymorphism
- UniSTS:144729

AI528556 (e-PCR)
- UniSTS:179454

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within UMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within UMP salvage	IC Inferred by Curator more info	PubMed
involved_in UMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uridine-cytidine kinase 1

Names: cytidine monophosphokinase 1; uridine monophosphate kinase; uridine monophosphokinase 1

NP_001365720.1

EC 2.7.1.48

NP_001365721.1

EC 2.7.1.48

NP_035805.2

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378791.1 → NP_001365720.1 uridine-cytidine kinase 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/Swiss-Prot

P52623

Conserved Domains (1) summary

cd02023
Location:31 → 254

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
NM_001378792.1 → NP_001365721.1 uridine-cytidine kinase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/Swiss-Prot

P52623

Conserved Domains (1) summary

cd02023
Location:12 → 187

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
NM_011675.2 → NP_035805.2 uridine-cytidine kinase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AK132100, BY338721, CJ194826, L31783

Consensus CDS

CCDS15909.2

UniProtKB/Swiss-Prot

P52623

UniProtKB/TrEMBL

A2AN37

Related

ENSMUSP00000002625.9, ENSMUST00000002625.15

Conserved Domains (2) summary

COG0572
Location:24 → 238

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:31 → 236

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...