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Unc5c unc-5 netrin receptor C [ Mus musculus (house mouse) ]

Gene ID: 22253, updated on 20-Jul-2021

Summary

Official Symbol
Unc5cprovided by MGI
Official Full Name
unc-5 netrin receptor Cprovided by MGI
Primary source
MGI:MGI:1095412
See related
Ensembl:ENSMUSG00000059921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rcm; Unc5h; Unc5h3; B130051O18Rik
Expression
Biased expression in cerebellum adult (RPKM 4.5), limb E14.5 (RPKM 4.2) and 11 other tissues See more
Orthologs
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Genomic context

See Unc5c in Genome Data Viewer
Location:
3 H1; 3 65.57 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (141171325..141540685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141465564..141834924)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (141128528..141497886)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590L14 gene Neighboring gene predicted gene, 32875 Neighboring gene pyruvate dehydrogenase E1 alpha 2 Neighboring gene predicted gene 15689 Neighboring gene bone morphogenetic protein receptor, type 1B Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene PDZ and LIM domain 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Transgenic (2)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 6030473H24

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables netrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables netrin receptor activity involved in chemorepulsion IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
netrin receptor UNC5C
Names
UNC-5 homolog 3
rostral cerebellar malformation protein
unc-5 homolog C
unc5 homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293561.1NP_001280490.1  netrin receptor UNC5C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001280490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC157492, AC158552, AC170085, AK141181
    Consensus CDS
    CCDS80034.1
    UniProtKB/TrEMBL
    Q3UQ08, Q3URW2
    Related
    ENSMUSP00000074758.4, ENSMUST00000075282.10
    Conserved Domains (5) summary
    smart00218
    Location:547650
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:263314
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:169257
    I-set; Immunoglobulin I-set domain
    cd08799
    Location:863945
    Death_UNC5C; Death domain found in Uncoordinated-5C
    cl11960
    Location:171257
    Ig; Immunoglobulin domain
  2. NM_009472.4NP_033498.1  netrin receptor UNC5C isoform 2 precursor

    See identical proteins and their annotated locations for NP_033498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC157492, AC158552, AC170085
    Consensus CDS
    CCDS17873.1
    UniProtKB/Swiss-Prot
    O08747
    Related
    ENSMUSP00000101843.3, ENSMUST00000106236.9
    Conserved Domains (5) summary
    smart00218
    Location:528631
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:263314
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:169257
    I-set; Immunoglobulin I-set domain
    cd08799
    Location:844926
    Death_UNC5C; Death domain found in Uncoordinated-5C
    cl11960
    Location:171257
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    141171325..141540685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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