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Ranbp3l RAN binding protein 3-like [ Mus musculus (house mouse) ]

Gene ID: 223332, updated on 11-Apr-2024

Summary

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Official Symbol
Ranbp3lprovided by MGI
Official Full Name
RAN binding protein 3-likeprovided by MGI
Primary source
MGI:MGI:2444654
See related
Ensembl:ENSMUSG00000048424 AllianceGenome:MGI:2444654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130037N17Rik
Summary
Enables SMAD binding activity. Involved in mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and positive regulation of myoblast differentiation. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Orthologous to human RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 3.4), frontal lobe adult (RPKM 1.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Ranbp3l in Genome Data Viewer
Location:
15 A1; 15 3.82 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (8997209..9071355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (8967949..9067335)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene S-phase kinase-associated protein 2 Neighboring gene LMBR1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. Chernyakov D, et al. J Exp Clin Cancer Res, 2021 Jul 7. PMID 34233711, Free PMC Article
  2. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. Chen F, et al. Mol Cell Biol, 2015 May. PMID 25755279, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype.
    Title: Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype.
  2. Results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.
    Title: Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mesenchymal cell differentiation involved in bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ran-binding protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198024.2 → NP_932141.1  ran-binding protein 3-like

    See identical proteins and their annotated locations for NP_932141.1

    Status: VALIDATED

    Source sequence(s)
    AC119167, AK132406, BC058706
    UniProtKB/Swiss-Prot
    Q3V1J9, Q6PDH4
    Related
    ENSMUSP00000154327.3, ENSMUST00000227191.3
    Conserved Domains (1) summary
    cd13180
    Location:316 → 431
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    8997209..9071355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159318.1 → XP_036015211.1  ran-binding protein 3-like isoform X1

    Conserved Domains (1) summary
    cd13180
    Location:316 → 431
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  2. XM_036159319.1 → XP_036015212.1  ran-binding protein 3-like isoform X2

    Conserved Domains (1) summary
    cl17171
    Location:316 → 366
    PH-like; Pleckstrin homology-like domain

  3. XM_036159320.1 → XP_036015213.1  ran-binding protein 3-like isoform X3

    UniProtKB/TrEMBL
    A0A2I3BQU7
    Conserved Domains (1) summary
    cd13180
    Location:195 → 310
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  4. XM_036159321.1 → XP_036015214.1  ran-binding protein 3-like isoform X4

    Conserved Domains (1) summary
    cd13180
    Location:72 → 187
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDH4.1 GenPept UniProtKB/Swiss-Prot:Q6PDH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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