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Slc32a1 solute carrier family 32 (GABA vesicular transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 22348, updated on 23-Jun-2022

Summary

Official Symbol
Slc32a1provided by MGI
Official Full Name
solute carrier family 32 (GABA vesicular transporter), member 1provided by MGI
Primary source
MGI:MGI:1194488
See related
Ensembl:ENSMUSG00000037771 AllianceGenome:MGI:1194488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VGAT; Viaat; R75019
Summary
Enables gamma-aminobutyric acid:proton symporter activity and glycine transmembrane transporter activity. Acts upstream of or within glycine transport. Located in several cellular components, including cone cell pedicle; dendrite terminus; and inhibitory synapse. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; nervous system; and skeleton. Used to study temporal lobe epilepsy. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 56.5), frontal lobe adult (RPKM 42.0) and 5 other tissues See more
Orthologs
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Genomic context

See Slc32a1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158449180..158457667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158607260..158615747)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (158436494..158441483)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 40 Neighboring gene adipogenin Neighboring gene predicted gene 14204 Neighboring gene ARP5 actin-related protein 5 Neighboring gene microRNA 3474 Neighboring gene protein phosphatase 1, regulatory subunit 16B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gamma-aminobutyric acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gamma-aminobutyric acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glycine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in cone cell pedicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in dendrite terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
is_active_in integral component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in neuron projection terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
vesicular inhibitory amino acid transporter
Names
GABA and glycine transporter
mVGAT
mVIAAT
solute carrier family 32 member 1
vasicular inhibitory amino acid transporter 10D
vesicular GABA transporter a form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009508.2NP_033534.2  vesicular inhibitory amino acid transporter

    See identical proteins and their annotated locations for NP_033534.2

    Status: VALIDATED

    Source sequence(s)
    BC052020, BU053322
    Consensus CDS
    CCDS38309.1
    UniProtKB/Swiss-Prot
    O35633
    UniProtKB/TrEMBL
    Q49S98
    Related
    ENSMUSP00000036299.5, ENSMUST00000045738.5
    Conserved Domains (1) summary
    pfam01490
    Location:115512
    Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158449180..158457667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249493.1XP_030105353.1  vesicular inhibitory amino acid transporter isoform X1

    Conserved Domains (1) summary
    pfam01490
    Location:115512
    Aa_trans; Transmembrane amino acid transporter protein