Abra actin-binding Rho activating protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abraprovided by MGI
Official Full Name: actin-binding Rho activating proteinprovided by MGI
Primary source: MGI:MGI:2444891
See related: Ensembl:ENSMUSG00000042895 AllianceGenome:MGI:2444891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STARS; C130068O12Rik
Summary: Enables actin binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of Rho protein signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein import into nucleus. Located in actin cytoskeleton and myofibril. Is expressed in embryo; heart; hindlimb muscle; and skeletal muscle. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 5.2), mammary gland adult (RPKM 1.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 16.42 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (41728689..41733116, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (41865293..41869720, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways.
Title: Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways.
STARS expression signaling is necessary for skeletal myotube survival but does not influence protein synthesis or degradation.
Title: Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation.
GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease
Title: Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4.
ABLIM-2 and -3 associate with STARS and directly bind F-actin
Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.
Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between myocyte enhancer factor-2 and serum response factor.
Title: Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.
a novel striated muscle activator of Rho signaling and serum response factor-dependent transcription (striated muscle activator of Rho signaling; STARS)
Title: STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in sarcomere	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-binding Rho-activating protein

Names: striated muscle activator of Rho-dependent signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.