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Vldlr very low density lipoprotein receptor [ Mus musculus (house mouse) ]

Gene ID: 22359, updated on 22-Aug-2021

Summary

Official Symbol
Vldlrprovided by MGI
Official Full Name
very low density lipoprotein receptorprovided by MGI
Primary source
MGI:MGI:98935
See related
Ensembl:ENSMUSG00000024924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA408956; AI451093; AW047288
Expression
Broad expression in heart adult (RPKM 21.6), subcutaneous fat pad adult (RPKM 8.9) and 17 other tissues See more
Orthologs
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Genomic context

See Vldlr in Genome Data Viewer
Location:
19 C1; 19 21.77 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (27190070..27231631)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (27216480..27254231)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (27291510..27328721)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931403E22 gene Neighboring gene predicted gene, 46648 Neighboring gene predicted gene 815 Neighboring gene predicted gene, 35438 Neighboring gene predicted gene, 35268 Neighboring gene potassium channel, subfamily V, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables reelin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables reelin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables very-low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables very-low-density lipoprotein particle receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
very low-density lipoprotein receptor
Names
VLDL receptor
VLDL-R

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161420.1NP_001154892.1  very low-density lipoprotein receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001154892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC119982, AK036010, AK076172, AK136838, BU504025, U06670
    Consensus CDS
    CCDS50411.1
    UniProtKB/Swiss-Prot
    P98156
    UniProtKB/TrEMBL
    Q3UVX6, Q91YY0
    Related
    ENSMUSP00000126730.2, ENSMUST00000172302.8
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_001347441.1NP_001334370.1  very low-density lipoprotein receptor isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC119982, AI451093
    Consensus CDS
    CCDS84429.1
    UniProtKB/TrEMBL
    F8WGI9
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:467506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:355385
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:196232
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:527567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:319353
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. NM_013703.2NP_038731.2  very low-density lipoprotein receptor isoform a precursor

    See identical proteins and their annotated locations for NP_038731.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AC119982, AK036010, AK076172, AK136838, BU504025, U06670
    Consensus CDS
    CCDS29721.1
    UniProtKB/Swiss-Prot
    P98156
    UniProtKB/TrEMBL
    Q3UVX6
    Related
    ENSMUSP00000127329.2, ENSMUST00000167487.8
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    27190070..27231631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161519.1XP_036017412.1  very low-density lipoprotein receptor isoform X6

    Conserved Domains (5) summary
    smart00135
    Location:488530
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:292322
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:133169
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:464504
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:256290
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_006526917.2XP_006526980.1  very low-density lipoprotein receptor isoform X1

    See identical proteins and their annotated locations for XP_006526980.1

    UniProtKB/Swiss-Prot
    P98156
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. XM_030250866.2XP_030106726.1  very low-density lipoprotein receptor isoform X2

    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  4. XM_030250868.2XP_030106728.1  very low-density lipoprotein receptor isoform X5

    Conserved Domains (5) summary
    smart00135
    Location:488530
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:292322
    EGF_CA; Calcium-binding EGF-like domain
    pfam00058
    Location:464504
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:133169
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:256290
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  5. XM_006526919.4XP_006526982.1  very low-density lipoprotein receptor isoform X3

    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:467506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:355385
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:527567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:196232
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:319353
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  6. XM_036161517.1XP_036017410.1  very low-density lipoprotein receptor isoform X4

    Related
    ENSMUSP00000049145.7, ENSMUST00000047645.13
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:467506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:355385
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:196232
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:527567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:319353
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  7. XM_030250865.2XP_030106725.1  very low-density lipoprotein receptor isoform X1

    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  8. XM_006526918.4XP_006526981.1  very low-density lipoprotein receptor isoform X1

    See identical proteins and their annotated locations for XP_006526981.1

    UniProtKB/Swiss-Prot
    P98156
    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  9. XM_036161516.1XP_036017409.1  very low-density lipoprotein receptor isoform X2

    Conserved Domains (7) summary
    smart00192
    Location:71103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:237273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  10. XM_036161518.1XP_036017411.1  very low-density lipoprotein receptor isoform X6

    Conserved Domains (5) summary
    smart00135
    Location:488530
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:292322
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:133169
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:464504
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:256290
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. XR_386457.4 RNA Sequence

  2. XR_003952777.2 RNA Sequence

  3. XR_003952778.2 RNA Sequence

  4. XR_004940134.1 RNA Sequence

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