Vnn1 vanin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vnn1provided by MGI
Official Full Name: vanin 1provided by MGI
Primary source: MGI:MGI:108395
See related: Ensembl:ENSMUSG00000037440 AllianceGenome:MGI:108395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V-1
Summary: Predicted to enable pantetheine hydrolase activity. Involved in several processes, including chronic inflammatory response; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and positive regulation of T cell differentiation in thymus. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; facial bone primordium; genitourinary system; nervous system; and respiratory system. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 31.3), placenta adult (RPKM 24.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.33 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23770586..23781242)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23894688..23905344)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction.
Title: Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction.
VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing beta-cell dedifferentiation.
Title: VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing β‑cell dedifferentiation.
Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Title: Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFkappaB-mediated inflammation in IUGR mice.
Title: Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice.
upregulating miR-203 can alleviate lung injury through activation of the AKT signaling pathway by downregulating VNN1 in septic shock.
Title: MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1.
This study reports the design, synthesis, and biological examination of a highly sensitive bioluminogenic probe for pantetheinase with a limit of detection of 1.14 ng/mL. Starvation elevated the bioluminescence intensity of the mice due to the upregulation of the pantetheinase activity.
Title: Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation.
hese results indicate that mice lacking Vnn1 have deficiencies in compensatory repair and immune responses following toxic APAP exposure and that these mechanisms may contribute to the enhanced hepatotoxicity seen.
Title: Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.
The data demonstrate that vanin-1/pantetheinase controls fibrosis, vasculopathy, autoimmunity, and oxidative stress in Systemic sclerosis (SSc).
Title: Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
oxidized LDL (Ox-LDL) can significantly induce VNN1 expression through an ERK1/2/cyclooxygenase-2 (COX-2)/PPARalpha signaling pathway.
Title: VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
absence of vanin-1 activity improves insulin sensitivity.
Title: Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Vnn1 (e-PCR), detects polymorphism
- UniSTS:464698

Vnn1 (e-PCR), detects polymorphism
- UniSTS:525953

NoName (e-PCR)
- UniSTS:224195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	TAS Traceable Author Statement more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables pantetheine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantetheine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables pantetheine hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in chronic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in nitrogen compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pantothenate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pantetheinase

Names: pantetheine hydrolase; vascular non-inflammatory molecule 1

NP_035834.2

EC 3.5.1.92

XP_006512781.1

EC 3.5.1.92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428877.1 → NP_001415806.1 pantetheinase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC153973
NM_001428878.1 → NP_001415807.1 pantetheinase isoform 3

Status: VALIDATED

Source sequence(s)

AC153973
NM_011704.4 → NP_035834.2 pantetheinase isoform 1 precursor

See identical proteins and their annotated locations for NP_035834.2

Status: VALIDATED

Source sequence(s)

AC153973

Consensus CDS

CCDS35868.1

UniProtKB/Swiss-Prot

Q3TJI0, Q8VCT1, Q9DCH8, Q9Z0K8

Related

ENSMUSP00000040599.8, ENSMUST00000041416.8

Conserved Domains (1) summary

cd07567
Location:27 → 324

biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

23770586..23781242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512718.3 → XP_006512781.1 pantetheinase isoform X1

UniProtKB/TrEMBL

Q3UEK0

Conserved Domains (1) summary

cl11424
Location:1 → 184

nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes