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Vwf Von Willebrand factor [ Mus musculus (house mouse) ]

Gene ID: 22371, updated on 11-Jul-2021

Summary

Official Symbol
Vwfprovided by MGI
Official Full Name
Von Willebrand factorprovided by MGI
Primary source
MGI:MGI:98941
See related
Ensembl:ENSMUSG00000001930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VWD; F8VWF; AI551257; C630030D09; 6820430P06Rik; B130011O06Rik
Expression
Biased expression in lung adult (RPKM 49.3), heart adult (RPKM 9.7) and 9 other tissues See more
Orthologs
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Genomic context

See Vwf in Genome Data Viewer
Location:
6 F3; 6 59.32 cM
Exon count:
53
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125529911..125663642)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125552948..125686679)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125502981..125636695)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26728 Neighboring gene CD9 antigen Neighboring gene predicted gene, 33144 Neighboring gene anoctamin 2 Neighboring gene predicted gene, 38898 Neighboring gene predicted gene, 33202

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemostasis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
von Willebrand factor
Names
Von Willebrand factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011708.4NP_035838.3  von Willebrand factor precursor

    See identical proteins and their annotated locations for NP_035838.3

    Status: VALIDATED

    Source sequence(s)
    AC153580, AY208897, BF662502, BI133662
    Consensus CDS
    CCDS20552.1
    UniProtKB/Swiss-Prot
    Q8CIZ8
    UniProtKB/TrEMBL
    E9QPU1
    Related
    ENSMUSP00000107873.3, ENSMUST00000112254.8
    Conserved Domains (11) summary
    smart00041
    Location:27272808
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:24312494
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:377540
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:12771449
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:10531127
    C8; This domain contains 8 conserved cysteine residues
    pfam00092
    Location:14981658
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:35179
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:295348
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:580648
    C8; C8 domain
    pfam16164
    Location:11981276
    VWA_N2; VWA N-terminal
    cl17735
    Location:25822644
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125529911..125663642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505918.5XP_006505981.1  von Willebrand factor isoform X1

    Conserved Domains (12) summary
    smart00041
    Location:26632744
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:23672430
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:313476
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:12131385
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:9891063
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:25182580
    VWC; von Willebrand factor type C domain
    pfam00092
    Location:14341594
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:803947
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:231284
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:520584
    C8; C8 domain
    pfam16164
    Location:11341212
    VWA_N2; VWA N-terminal
    cl02516
    Location:19113
    VWD; von Willebrand factor type D domain
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