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Marf1 meiosis regulator and mRNA stability 1 [ Mus musculus (house mouse) ]

Gene ID: 223989, updated on 21-Apr-2024

Summary

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Official Symbol
Marf1provided by MGI
Official Full Name
meiosis regulator and mRNA stability 1provided by MGI
Primary source
MGI:MGI:2444505
See related
Ensembl:ENSMUSG00000060657 AllianceGenome:MGI:2444505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lkap; mKIAA0430; E030019O05; 4921513D23Rik
Summary
Predicted to enable CCR4-NOT complex binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Acts upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; oocyte; and sensory organ. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 10.6), frontal lobe adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 9.69 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13927030..13977157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14109166..14159278, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene bMERB domain containing 1 Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like Neighboring gene Y box protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7428 Neighboring gene STARR-positive B cell enhancer ABC_E4155 Neighboring gene microRNA 484 Neighboring gene STARR-seq mESC enhancer starr_40176 Neighboring gene nudE neurodevelopment protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Yao Q, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30333187, Free PMC Article
  2. Interference with the C-terminal structure of MARF1 causes defective oocyte meiotic division and female infertility in mice. Cao GY, et al. J Biomed Res, 2018 Jan 18. PMID 29353819, Free PMC Article
  3. The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Kanemitsu Y, et al. Sci Rep, 2017 Apr 25. PMID 28442784, Free PMC Article
  4. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Su YQ, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23090997, Free PMC Article
  5. A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Fujitani M, et al. Mol Psychiatry, 2017 Mar. PMID 27378146, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Purified MARF1 cleaved ssRNAs in vitro.
    Title: Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice.
  2. Here, the authors report that meiosis arrest female 1 (MARF1) is an RBP that is expressed during neuronal differentiation. Cortical neurons expressed the somatic form of MARF1 (sMARF1) but not the oocyte form (oMARF1). sMARF1 was enriched in embryonic brains, and its expression level decreased as brain development progressed.
    Title: The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain.
  3. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.
    Title: Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.
  4. MARF1 (4921513D23Rik), by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring
    Title: MARF1 regulates essential oogenic processes in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0430, MGC36956

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR4-NOT complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
meiosis regulator and mRNA stability factor 1
Names
limkain-b1
meiosis arrest female 1
meiosis arrest female protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081154.2 → NP_001074623.1  meiosis regulator and mRNA stability factor 1

    Status: VALIDATED

    Source sequence(s)
    AC119853, AC164291
    Consensus CDS
    CCDS37262.1
    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Related
    ENSMUSP00000087770.5, ENSMUST00000090300.6
    Conserved Domains (10) summary
    cd09978
    Location:1002 → 1072
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:1098 → 1169
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:1174 → 1245
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:1258 → 1328
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:1410 → 1482
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:1485 → 1560
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd10910
    Location:351 → 493
    limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
    cd12255
    Location:508 → 580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:785 → 873
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cl14879
    Location:1334 → 1404
    LabA_like_C; C-terminal domain of LabA_like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13927030..13977157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522018.4 → XP_006522081.1  meiosis regulator and mRNA stability factor 1 isoform X1

    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Conserved Domains (10) summary
    cd09978
    Location:988 → 1058
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:1084 → 1155
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:1160 → 1231
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:1244 → 1314
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:1396 → 1468
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:1471 → 1546
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd12255
    Location:508 → 580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:771 → 859
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cd10910
    Location:351 → 473
    PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
    cl14879
    Location:1320 → 1390
    LabA_like_C; C-terminal domain of LabA_like proteins

  2. XM_006522019.3 → XP_006522082.1  meiosis regulator and mRNA stability factor 1 isoform X2

    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Conserved Domains (10) summary
    cd09978
    Location:1002 → 1072
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:1098 → 1169
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:1174 → 1245
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:1258 → 1328
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:1410 → 1482
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:1485 → 1560
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd12255
    Location:508 → 580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:785 → 873
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cd10910
    Location:351 → 473
    PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
    cl14879
    Location:1334 → 1404
    LabA_like_C; C-terminal domain of LabA_like proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ34.3 GenPept UniProtKB/Swiss-Prot:Q8BJ34

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