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Scarf2 scavenger receptor class F, member 2 [ Mus musculus (house mouse) ]

Gene ID: 224024, updated on 11-Apr-2024

Summary

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Official Symbol
Scarf2provided by MGI
Official Full Name
scavenger receptor class F, member 2provided by MGI
Primary source
MGI:MGI:1858430
See related
Ensembl:ENSMUSG00000012017 AllianceGenome:MGI:1858430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSR1; Srec2; Scatf1; SrecII; SREC-II; SRECRP-1
Summary
Enables scavenger receptor activity. Acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; metanephros; skin; thoracic segment skeleton; and trachea. Human ortholog(s) of this gene implicated in Van den Ende-Gupta syndrome. Orthologous to human SCARF2 (scavenger receptor class F member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 105.4), ovary adult (RPKM 99.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Scarf2 in Genome Data Viewer
Location:
16 A3; 16 11.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17615146..17626158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17797282..17808294)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene biorientation of chromosomes in cell division 1, pseudogene Neighboring gene kelch-like 22 Neighboring gene VISTA enhancer mm1629 Neighboring gene zinc finger protein 520, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40262 Neighboring gene family with sequence similarity 246 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. Berwin B, et al. J Biol Chem, 2004 Dec 3. PMID 15371419
  2. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. Tamura Y, et al. J Biol Chem, 2004 Jul 23. PMID 15145948
  3. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095
  4. Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Bildsoe H, et al. Dev Biol, 2016 Oct 1. PMID 27546376
  5. Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2. Lund J, et al. Genomics, 2000 Feb 1. PMID 10704284

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binds to SRECI and has a similar tissue distribution pattern
    Title: SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
  2. SREC-I is a type F scavenger receptor and an endocytic receptor for calreticulin
    Title: SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.
  3. role of scavenger receptor expressed by endothelial cells I (SREC-I) in the uptake of modified lipoproteins as well as in the development of atherosclerosis
    Title: Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scavenger receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
scavenger receptor class F member 2
Names
scavenger receptor expressed by endothelial cells 2 (acetyl LDL receptor like)
scavenger receptor type F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153790.3 → NP_722485.1  scavenger receptor class F member 2 precursor

    See identical proteins and their annotated locations for NP_722485.1

    Status: VALIDATED

    Source sequence(s)
    AC078895, AF522197, BC059226
    Consensus CDS
    CCDS28010.1
    UniProtKB/Swiss-Prot
    P59222
    UniProtKB/TrEMBL
    Q58A84
    Related
    ENSMUSP00000012161.4, ENSMUST00000012161.5
    Conserved Domains (1) summary
    PRK12798
    Location:715 → 832
    PRK12798; chemotaxis protein; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17615146..17626158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159884.1 → XP_036015777.1  scavenger receptor class F member 2 isoform X1

    Related
    ENSMUST00000231329.2
    Conserved Domains (3) summary
    PHA03247
    Location:683 → 838
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:526 → 836
    PHA03307; transcriptional regulator ICP4; Provisional
    NF033759
    Location:74 → 431
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_036159886.1 → XP_036015779.1  scavenger receptor class F member 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:457 → 612
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:300 → 610
    PHA03307; transcriptional regulator ICP4; Provisional
    NF033759
    Location:6 → 205
    exchanger_TraA; outer membrane exchange protein TraA

  3. XM_036159885.1 → XP_036015778.1  scavenger receptor class F member 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:457 → 612
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:300 → 610
    PHA03307; transcriptional regulator ICP4; Provisional
    NF033759
    Location:6 → 205
    exchanger_TraA; outer membrane exchange protein TraA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59222.1 GenPept UniProtKB/Swiss-Prot:P59222

Gene LinkOut

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