Muc20 mucin 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc20provided by MGI
Official Full Name: mucin 20provided by MGI
Primary source: MGI:MGI:2385039
See related: Ensembl:ENSMUSG00000035638 AllianceGenome:MGI:2385039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within hepatocyte growth factor receptor signaling pathway and positive regulation of MAPK cascade. Predicted to be located in basal plasma membrane. Is expressed in metanephros. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human MUC20 (mucin 20, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 9.0), colon adult (RPKM 3.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 23.34 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (32597793..32617805, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (32777419..32797435, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway.
Title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Muc4 (e-PCR), detects polymorphism
- UniSTS:239203

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in hepatocyte growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hepatocyte growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mucin-20

Names: MUC-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145874.1 → NP_001139346.1 mucin-20 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK142548, AK165477, BB615450, MG954261

Consensus CDS

CCDS49829.1

UniProtKB/TrEMBL

E9PUF1

Related

ENSMUSP00000110769.2, ENSMUST00000115116.8

Conserved Domains (1) summary

PRK11907
Location:151 → 266

PRK11907; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed
NM_146071.2 → NP_666183.2 mucin-20 isoform b precursor

See identical proteins and their annotated locations for NP_666183.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK165477, BB661244

Consensus CDS

CCDS49830.1

UniProtKB/Swiss-Prot

Q76I84, Q8BUE7, Q8R0X0

Related

ENSMUSP00000041221.9, ENSMUST00000041123.9

Conserved Domains (1) summary

pfam05687
Location:174 → 234

BES1_N; BES1/BZR1 plant transcription factor, N-terminal