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Golgb1 golgin B1 [ Mus musculus (house mouse) ]

Gene ID: 224139, updated on 5-Mar-2024

Summary

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Official Symbol
Golgb1provided by MGI
Official Full Name
golgin B1provided by MGI
Primary source
MGI:MGI:1099447
See related
Ensembl:ENSMUSG00000034243 AllianceGenome:MGI:1099447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
628101; Gm6840; mKIAA4151; 4930428L02Rik; 6330407A06Rik; C130074L01Rik; F730017E11Rik
Summary
Predicted to be involved in chondrocyte proliferation and protein localization to pericentriolar material. Located in cis-Golgi network. Is expressed in several structures, including embryo endoderm; face; limb; limb bud; and nervous system. Used to study cleft palate. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.4), placenta adult (RPKM 9.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 26.19 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36695455..36753447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36875093..36933085)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 15 (H+/peptide transporter), member 2 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E764 Neighboring gene ELL associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1185 Neighboring gene STARR-positive B cell enhancer ABC_E10903 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5541 Neighboring gene STARR-positive B cell enhancer ABC_E99 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene STARR-seq mESC enhancer starr_40776 Neighboring gene STARR-positive B cell enhancer ABC_E8632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:36932162-36932315 Neighboring gene STARR-positive B cell enhancer ABC_E7446 Neighboring gene STARR-positive B cell enhancer ABC_E4169 Neighboring gene hematopoietic cell specific Lyn substrate 1 Neighboring gene STARR-seq mESC enhancer starr_40777 Neighboring gene F-box protein 40 Neighboring gene STARR-seq mESC enhancer starr_40778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Lan Y, et al. Development, 2016 Jul 1. PMID 27226319, Free PMC Article
  2. Golga5 is dispensable for mouse embryonic development and postnatal survival. McGee LJ, et al. Genesis, 2017 Jul. PMID 28509431, Free PMC Article
  3. Characterization of the INT6 mammary tumor gene product. Diella F, et al. DNA Cell Biol, 1997 Jul. PMID 9260927
  4. Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice. Wang G, et al. Cell Biosci, 2016. PMID 27293546, Free PMC Article
  5. Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Kurth I, et al. Nat Genet, 2009 Nov. PMID 19838196

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golgb1 has specific functions in protein glycosylation and tissue morphogenesis.
    Title: Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4151, MGC183642

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
golgin subfamily B member 1
Names
giantin
golgi autoantigen, golgin subfamily b, macrogolgin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030035.1 → NP_084311.1  golgin subfamily B member 1

    See identical proteins and their annotated locations for NP_084311.1

    Status: VALIDATED

    Source sequence(s)
    AC154763
    Consensus CDS
    CCDS49844.1
    UniProtKB/TrEMBL
    B2RWW2, E9PVZ8
    Conserved Domains (3) summary
    COG1196
    Location:1837 → 2656
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1167 → 1242
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1331 → 2164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36695455..36753447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522082.3 → XP_006522145.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_006522145.1

    UniProtKB/TrEMBL
    B2RWW2, E9PVZ8
    Conserved Domains (3) summary
    COG1196
    Location:1837 → 2656
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1167 → 1242
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1331 → 2164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006522084.5 → XP_006522147.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_006522147.1

    UniProtKB/TrEMBL
    B2RWW2, E9PVZ8
    Related
    ENSMUSP00000045239.9, ENSMUST00000039855.9
    Conserved Domains (3) summary
    COG1196
    Location:1837 → 2656
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1167 → 1242
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1331 → 2164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_030249086.2 → XP_030104946.1  golgin subfamily B member 1 isoform X2

    UniProtKB/TrEMBL
    B2RWW2
    Conserved Domains (4) summary
    COG1196
    Location:1831 → 2650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:49 → 118
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:1161 → 1236
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1325 → 2158
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_030249088.1 → XP_030104948.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    B2RWW2, E9QAH1
    Conserved Domains (4) summary
    COG1196
    Location:1796 → 2615
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:49 → 118
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:1126 → 1201
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1290 → 2123
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_017316964.2 → XP_017172453.1  golgin subfamily B member 1 isoform X1

    UniProtKB/TrEMBL
    B2RWW2, E9PVZ8
    Conserved Domains (3) summary
    COG1196
    Location:1837 → 2656
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1167 → 1242
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1331 → 2164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_017316963.3 → XP_017172452.1  golgin subfamily B member 1 isoform X1

    UniProtKB/TrEMBL
    B2RWW2, E9PVZ8
    Conserved Domains (3) summary
    COG1196
    Location:1837 → 2656
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1167 → 1242
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1331 → 2164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_017316965.2 → XP_017172454.1  golgin subfamily B member 1 isoform X3

    UniProtKB/TrEMBL
    B2RWW2
    Conserved Domains (3) summary
    COG1196
    Location:1799 → 2618
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12704
    Location:1129 → 1204
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1293 → 2126
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_030249087.2 → XP_030104947.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    B2RWW2, E9QAH1
    Conserved Domains (4) summary
    COG1196
    Location:1796 → 2615
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:49 → 118
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:1126 → 1201
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1290 → 2123
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_017316966.2 → XP_017172455.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    B2RWW2, E9QAH1
    Related
    ENSMUSP00000110460.2, ENSMUST00000114812.9
    Conserved Domains (4) summary
    COG1196
    Location:1796 → 2615
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:49 → 118
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:1126 → 1201
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1290 → 2123
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_011245881.2 → XP_011244183.1  golgin subfamily B member 1 isoform X2

    See identical proteins and their annotated locations for XP_011244183.1

    UniProtKB/TrEMBL
    B2RWW2
    Conserved Domains (4) summary
    COG1196
    Location:1831 → 2650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:49 → 118
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:1161 → 1236
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:1325 → 2158
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_036159899.1 → XP_036015792.1  golgin subfamily B member 1 isoform X5

    UniProtKB/TrEMBL
    B2RWW2
    Conserved Domains (4) summary
    COG1196
    Location:1758 → 2577
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:11 → 80
    alaS; alanyl-tRNA synthetase; Reviewed
    TIGR02168
    Location:173 → 958
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    NF033930
    Location:1506 → 1892
    pneumo_PspA; pneumococcal surface protein A

RNA

  1. XR_003951781.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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