Wnt3a wingless-type MMTV integration site family, member 3A [ Mus musculus (house mouse) ]

Gene ID: 22416, updated on 21-Apr-2024

Summary

Official Symbol: Wnt3aprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 3Aprovided by MGI
Primary source: MGI:MGI:98956
See related: Ensembl:ENSMUSG00000009900 AllianceGenome:MGI:98956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: vt; Wnt-3a
Summary: Enables protein domain specific binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including COP9 signalosome assembly; calcium ion transmembrane transport via low voltage-gated calcium channel; and nervous system development. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 5.7), testis adult (RPKM 1.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 37.17 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (59138859..59181579, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (59248036..59290751, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIPK4 downregulation impairs Wnt3A-stimulated invasiveness via Wnt/beta-catenin signaling in melanoma cells and tumor growth in vivo.
Title: RIPK4 downregulation impairs Wnt3A-stimulated invasiveness via Wnt/β-catenin signaling in melanoma cells and tumor growth in vivo.
Abnormal activation of the Wnt3a/beta-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis.
Title: Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis.
PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a.
Title: PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a.
Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-alpha/IL-18 Expression in the Spinal Cord.
Title: Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-α/IL-18 Expression in the Spinal Cord.
Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
Title: Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
WNT3A-loaded exosomes enable cartilage repair.
Title: WNT3A-loaded exosomes enable cartilage repair.
Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis.
Title: Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis.
Joint single-cell multiomic analysis in Wnt3a induced asymmetric stem cell division.
Title: Joint single-cell multiomic analysis in Wnt3a induced asymmetric stem cell division.
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
Title: Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division.
Title: Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division.

Submit: New GeneRIF Correction See all GeneRIFs (198)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (4) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt3a (e-PCR), detects polymorphism
- UniSTS:508416

Wnt3a (e-PCR), detects polymorphism
- UniSTS:465420

Wnt3a (e-PCR), detects polymorphism
- UniSTS:471324

Wnt3a (e-PCR), detects polymorphism
- UniSTS:527138

Wnt3a (e-PCR), detects polymorphism
- UniSTS:265271

Wnt3a (e-PCR), detects polymorphism
- UniSTS:259458

Wnt3a (e-PCR), detects polymorphism
- UniSTS:259459

Wnt3a (e-PCR), detects polymorphism
- UniSTS:144778

Wnt3a (e-PCR), detects polymorphism
- UniSTS:516493

Wnt3a (e-PCR), detects polymorphism
- UniSTS:507318

PMC26484P1 (e-PCR)
- UniSTS:272339

Wnt3a (e-PCR), detects polymorphism
- UniSTS:508415

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in COP9 signalosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway involved in forebrain neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axis elongation involved in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport via low voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in forebrain	IDA Inferred from Direct Assay more info	PubMed
involved_in cell proliferation in midbrain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain development	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within paraxial mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dermatome development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of telomere maintenance via telomerase	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of RNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse to nucleus signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell division	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord association neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spinal cord association neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Wnt signalosome	IC Inferred by Curator more info	PubMed
part_of Wnt signalosome	NAS Non-traceable Author Statement more info	PubMed
part_of Wnt-Frizzled-LRP5/6 complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Wnt-3a

Names: vestigial tail; wingless-related MMTV integration site 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.